Testis of Hemidactylus flaviviridis, commonly known as Indian wall lizard, displays a lack of cellular and metabolic activity in regressed phase of testis during non-breeding season of the year. Retracted Sertoli cells (Sc), fibroid myoid cells and pre-meiotic resting spermatogonia are observed in such testis. This situation is akin to certain forms of infertility in men where hormone supplemen...

There is an urgent need to develop safe, effective dual-purpose contraceptive agents that combine the prevention of pregnancy with protection against sexually transmitted disease. Here we report the identification of a group of compounds that on contact with human spermatozoa induce a state of ‘spermostasis’, characterized by the extremely rapid inhibition of sperm movement without compromising...

Abstract Study question Whether and how METTL5 regulates germ cell development during spermatogenesis. Summary answer is required for spermiogenesis. Loss of resulted in teratozoospermia male infertility via reduced translation acrosome flagellum formation proteins. What known already The roles m6A modifications on mRNA spermatogenesis have been extensively studied. It was reported that knockou...

Alzheimer disease (AD) is the most common type of dementia and is characterized pathologically by the presence of neurofibrillary tangles (NFTs), senile plaques (SPs), and loss of synapses. The main component of SP is amyloid-beta peptide (Aβ), a 39 to 43 amino acid peptide, generated by the proteolytic cleavage of amyloid precursor protein (APP) by the action of beta- and gamma-secretases. The...

In men with ART failure, sperm DNA sequencing ultrastructural analysis can identify specific defects and guide treatment. the past 2 years, 22 consenting who failed IVF cycles due to severe astheno-/teratozoospermia were recruited; specimens from 3 fertile used as controls. To assess ultrastructure by transmission electron microscopy (TEM), pelleted spermatozoa fixed, embedded, sectioned 100-nm...