Ingenol mebutate (IM) is a topical pharmacotherapy approved in Switzerland since 2012 for treating non-hypertrophic, non-hyperkeratotic actinic keratosis (AK). We report 2 cases with off-label use of IM. The first case of bowenoid AK was treated with 150 μg IM for 3 consecutive days with an almost complete clinical remission of the lesion. The second case of Bowen's disease was treated with 500...

Let jν,k denote the k-th positive zero of the Bessel function Jν(x). In this paper, we prove that for ν > 0 and k = 1, 2, 3, . . . , ν − ak 21/3 ν < jν,k < ν − ak 21/3 ν + 3 20 ak 21/3 ν1/3 . These bounds coincide with the first few terms of the well-known asymptotic expansion jν,k ∼ ν − ak 21/3 ν + 3 20 ak 21/3 ν1/3 + · · · as ν →∞, k being fixed, where ak is the k-th negative zero of the Airy...

Let Mn be the set of n × n complex matrices, and for every A ∈ Mn, let Sp(A) denote the spectrum of A. For various types of products A1 ∗ · · · ∗ Ak on Mn, it is shown that a mapping φ : Mn → Mn satisfying Sp(A1 ∗ · · · ∗ Ak) = Sp(φ(A1) ∗ · · · ∗ φ(Ak)) for all A1, . . . , Ak ∈ Mn has the form X → ξS−1XS or A → ξS−1XtS for some invertible S ∈ Mn and scalar ξ. The result covers the special cases...

Software architectural knowledge (AK) is the integrated representation of the software architecture (SA) of a software-intensive system, the architectural design decisions, and the external context/environment. AK annotation using AK conceptual model is used to recover formal AK from SA documentation, including architecture design as well as the design decisions, rationale, context, and other f...

In multicellular organisms p53 maintains genomic integrity through activation of DNA repair, and apoptosis. EBNA3C can down regulate p53 transcriptional activity. Aurora kinase (AK) B phosphorylates p53, which leads to degradation of p53. Aberrant expression of AK-B is a hallmark of numerous human cancers. Therefore changes in the activities of p53 due to AK-B and EBNA3C expression is important...

acanthamoeba keratitis (ak) is a sight-threating infection of the cornea that mostly affects contact lens wearers. until now, ak treatment remains very difficult due to the existence of a highly resistant cyst stage in the life cycle of acanthamoeba which is extremely resistant to most of the available anti-amoebic compounds. moreover, current treatment of ak is usually based in the combination...

BACKGROUND Previous studies suggest that adenylate kinase locus 1 (Ak 1 ) has an important role in the control of blood glucose level and in the glycation of structural and functional proteins in type 2 diabetes and in the balanced development of feto-placental unit in healthy puerperae (HP). In this study, an attempt was made to investigate the relationship of Ak 1 with maternal and neonatal p...

We present a new approach to evaluating combinatorial sums by using finite differences. Let {ak}k=0 and {bk}k=0 be sequences with the property that ∆bk = ak for k ≥ 0. Let gn = ∑n k=0 ( n k ) ak, and let hn = ∑n k=0 ( n k ) bk. We derive expressions for gn in terms of hn and for hn in terms of gn. We then extend our approach to handle binomial sums of the form ∑n k=0 ( n k ) (−1)ak, ∑ k ( n 2k ...