Twenty-three patients with angiocentric immunoproliferative lesions (AILs) including angiocentric lymphoma were evaluated clinically and pathologically. Pathologic subclassification performed without knowledge of the clinical outcome divided the cases into three histologic grades on the basis of cellular atypia and degree of inflammatory background. Immunophenotypic studies of lesions from six ...

Accurate estimates of recombination rates are of great importance for understanding evolution. In an experimental genetic cross, recombination breaks apart and rejoins genetic material, such that the genomes of the resulting isolates are comprised of distinct blocks of differing parental origin. We here describe a method exploiting this fact to infer genome-wide recombination profiles from sequ...

DIAL (dihedral alignment) is a web server that provides public access to a new dynamic programming algorithm for pairwise 3D structural alignment of RNA. DIAL achieves quadratic time by performing an alignment that accounts for (i) pseudo-dihedral and/or dihedral angle similarity, (ii) nucleotide sequence similarity and (iii) nucleotide base-pairing

Open Access Despite the fact that there is no dearth of talent in Pakistan, our contributions to medical literature and research is very negligible as compared to other Muslim countries like Islamic Republic of Iran, Turkey and even Saudi Arabia. Even our neighboring countries like India and Bangladesh have made tremendous progress during the last two decades but our performance in this field l...

Diabetes is a major global problem. During the past decade, the genetic basis of various monogenic forms of the disease, and their underlying molecular mechanisms, have been elucidated. Many genes that increase type 2 diabetes (T2DM) risk have also been identified, but how they do so remains enigmatic. Nevertheless, defective insulin secretion emerges as the main culprit in both monogenic and p...

One of the problems tourism faces is how to make itineraries more effective and efficient. This research has solved the routing problem with the objective of maximizing the score and minimizing the time needed for the tourist’s itinerary. Maximizing the score means collecting a maximum of various kinds of score from each destination that is visited. The profits differ according to whether those...