BACKGROUND There is scant evidence on the effect that chronic kidney disease (CKD) confers on clinically meaningful outcomes among patients with heart failure with preserved left ventricular ejection fraction (HF-PEF). METHODS AND RESULTS We identified a community-based cohort of patients with HF. Electronic medical record data were used to divide into HF-PEF and reduced left ventricular EF o...

This editorial refers to ‘‘Characterization of acute heart failure hospitalizations in a Portuguese cardiology department’’ by A.C. Pinho-Gomes et al. Acute heart failure (AHF) is a highly prevalent condition, a common cause of hospitalization associated with significant in-hospital mortality and poor shortand longer-term outcomes, and represents a significant burden on overall healthcare costs...

Vasodilator therapy is common in acute heart failure (AHF) patients, although evidence for morbidity and mortality benefits is limited for many of these drugs. AHF is frequently accompanied by renal dysfunction, which is a strong, independent predictor for poor prognosis. Several hemodynamic and neurohormonal effects of vasodilators—including preload and afterload reduction, activation or inhib...

HEART FAILURE (HF) WITH preserved ejection fraction (EF) accounts for more than 50% of the total HF population. Community-based cohort studies have shown that mortality rates are similar in HF with preserved EF compared with HF with reduced EF, but data from large clinical trials point toward a better outcome in HF with preserved EF. This may indicate that comorbidities that are typically exclu...

Acute heart failure (AHF) is one of the main causes of cardiovascular morbidity and mortality. After diagnosis of AHF and during the first year of followup, 45% of the patients will be admitted to hospital at least once and mortality can be as high as 40%.1 Therapeutic approaches are therefore needed to alleviate symptoms, stabilize the hemodynamics of the patients, and improve their quality of...

BACKGROUND International geographic differences in outcomes may exist for clinical trials of heart failure and reduced ejection fraction (HF-REF), but there are few data for those with preserved ejection fraction (HF-PEF). METHODS AND RESULTS We analyzed outcomes by international geographic region in the Irbesartan in Heart Failure with Preserved systolic function trial (I-Preserve), the Cand...

The emergency department (ED) accounts for 80% of hospital admissions due to acute heart failure (AHF). Further, because of their multiple comorbidities, approximately 80% of ED patients with AHF are admitted to the hospital, the majority to a telemetry floor. Most of these patients present with worsening chronic heart failure, requiring and benefiting from urgent ED‐based intravenous therapy. ...

Abstract Worsening kidney function (WKF) is common in patients with acute heart failure (AHF) syndromes. Although WKF has traditionally been associated worse outcomes on a population level, serum creatinine concentrations vary greatly during episodes of worsening failure, substantial individual heterogeneity terms their clinical meaning. Consequently, interpreting such changes within the approp...

Arterial stiffness contributes to the development of cardiovascular disease (CVD). However, relationship between arterial and exercise tolerance in CVD patients with preserved ejection fraction (pEF) those reduced EF (rEF) is unclear. We enrolled 358 who participated cardiac rehabilitation underwent cardiopulmonary testing at Juntendo University Hospital. After excluding 195 had undergone open ...

BACKGROUND Elevated red blood cell distribution width (RDW) is a valid predictor of outcome in acute heart failure (AHF). It is unknown whether elevated RDW remains predictive in AHF patients with either preserved left ventricular ejection fraction (LVEF) ≥50% or reduced LVEF (<50%). METHODS AND RESULTS Prospective local registry including 402 consecutive hospitalized AHF patients without acu...