نتایج جستجو برای: agrp عضله

تعداد نتایج: 3660  

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2004
Diane E Day Timothy J Bartness

Agouti-related protein (AgRP), an endogenous melanocortin 3/4 receptor antagonist, appears to play an important role in the control of food intake and energy balance because exogenous administration in rats and overexpression in mice result in hyperphagia and body mass gain. Furthermore, arcuate nucleus AgRP mRNA is increased with fasting in laboratory rats and mice and is decreased with refeed...

2017
Chia-Shan Wu Odelia Y. N. Bongmba Jing Yue Jong Han Lee Ligen Lin Kenji Saito Geetali Pradhan De-Pei Li Hui-Lin Pan Allison Xu Shaodong Guo Yong Xu Yuxiang Sun

Ghrelin, an orexigenic hormone released primarily from the gut, signals the hypothalamus to stimulate growth hormone release, enhance appetite and promote weight gain. The ghrelin receptor, aka Growth Hormone Secretagogue Receptor (GHS-R), is highly expressed in the brain, with highest expression in Agouti-Related Peptide (AgRP) neurons of the hypothalamus. We recently reported that neuron-spec...

2015
Hongxia Ren Joshua R. Cook Ning Kon Domenico Accili

Hypothalamic neurons expressing agouti-related peptide (AgRP) regulate eating and glucose metabolism. Ablation of FOXO1 in AgRP neurons of mice results in reduced food intake, leanness, improved glucose homeostasis, and increased sensitivity to insulin and leptin. We tentatively identified G-protein-coupled receptor Gpr17 as an effector of FOXO1 orexigenic signals in AgRP neurons. In this study...

Journal: :Cell 2009
Qi Wu Maureen P. Boyle Richard D. Palmiter

Neurons in the arcuate nucleus that produce AgRP, NPY, and GABA (AgRP neurons) promote feeding. Ablation of AgRP neurons in adult mice results in Fos activation in postsynaptic neurons and starvation. Loss of GABA is implicated in starvation because chronic subcutaneous delivery of bretazenil (a GABA(A) receptor partial agonist) suppresses Fos activation and maintains feeding during ablation of...

ژورنال: :پژوهشنامه فیزیولوژی ورزشی کاربردی 2011
عبّاس قنبری نیاکی امیررشید لمیر مسلم حجّتی محمّد قاسمی

چکیده مقدّمه: agrp، یک نرو پپتید مترشحه از هستة کمانی هیپوتالاموس است و نقش مهمّی در تعادل انرژی، کنترل وزن و دریافت غذا ایفا می­کند. گزارش شده است که شرایط منفی تعادل انرژی، موجب افزایش مقادیر agrp می شود و با ایجاد شرایط مثبت تعادل انرژی ( بازسازی منابع انرژی) متوقّف می شود. هدف از اجرای این پژوهش، بررسی اثر مصرف قند خوراکی (گلوکز) پس از یک فعّالیّت دایره ای مقاومتی بر روی agrp، انسولین و گلوکز پل...

Journal: :Endocrinology 2003
Ennian Xiao Linna Xia-Zhang Nicolas R Vulliémoz Michel Ferin Sharon L Wardlaw

alpha-MSH antagonizes many of the immune and neuroendocrine effects induced by inflammatory cytokines. Studies have shown that alpha-MSH attenuates the stimulatory effect of IL-1 on the hypothalamic-pituitary-adrenal (HPA) axis and plays a physiological role in limiting the HPA response to IL-1. Recently an alpha-MSH antagonist, agouti-related protein (AGRP), has been identified in the hypothal...

2011
Jae Geun Kim Byong Seo Park Chang Ho Yun Hyun Jun Kim Sang Soo Kang Angela Valentina D’Elia Giuseppe Damante Ki-Up Lee Jeong Woo Park Eun Sook Kim Il Seong Namgoong Young Il Kim Byung Ju Lee

OBJECTIVE α-Melanocyte-stimulating hormone (α-MSH) and agouti-related peptide (AgRP) control energy homeostasis by their opposing actions on melanocortin receptors (MC3/4R) in the hypothalamus. We previously reported that thyroid transcription factor-1 (TTF-1) controls feeding behavior in the hypothalamus. This study aims to identify the function of TTF-1 in the transcriptional regulation of Ag...

Journal: :The Journal of biological chemistry 2006
Andreas Breit Katharina Wolff Hermann Kalwa Hubertus Jarry Thomas Büch Thomas Gudermann

Agouti-related protein (Agrp), one of the two naturally occurring inverse agonists known to inhibit G protein-coupled receptor activity, regulates energy expenditure by decreasing basal and blocking agonist-promoted melanocortin receptor (MCR) signaling. Here we report that, in addition to its inverse agonistic activities, Agrp exhibits agonistic properties on the endocytosis pathway of melanoc...

Journal: :The Journal of biological chemistry 1999
Y K Yang C J Dickinson Q Zeng J Y Li D A Thompson I Gantz

Agouti-related protein (AGRP) is an endogenous antagonist of melanocortin action that functions in the hypothalamic control of feeding behavior. Although previous studies have shown that AGRP binds three of the five known subtypes of melanocortin receptor, the receptor domains participating in binding and the molecular interactions involved are presently unknown. The present studies were design...

2007
W. S. Dhillo J. V. Gardiner L. Castle G. A. Bewick K. L. Smith K. Meeran J. F. Todd M. A. Ghatei

Alpha melanocyte stimulating hormone (α-MSH) is an agonist at the melanocortin 3 (MC3-R) and melanocortin 4 (MC4-R) receptors. α-MSH stimulates corticosterone release from rat and human adrenal cells. Patients with Cushing’s syndrome have elevated levels of serum α-MSH. Agouti related protein (AgRP) is an endogenous antagonist at the MC3-R and MC4-R and is expressed in the rat adrenal cortex. A...

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