Abstract Background The maintenance of genome stability is a key process to slow aging. One the mechanisms ensuring this correct coordination origins replication (ORI), resulting in successful transmission DNA. Previously, we mapped and compared ORI firing between young aged mice vivo, using regenerating liver mouse model. We confirmed decreased hepatocyte efficiency mice, known have impaired r...

conclusions it seem that melatonin due to its antioxidant properties, if added to glycerol based media, reduces the harmful effects of freezing-thawing process, and protects seminiferous tubules histological structure from oxidative injury. results the result showed that supplementation of glycerol based media with melatonin has reduced injury to histological structure of seminiferous tubules i...

Recovery after acute kidney injury is impaired in the elderly, but mechanistic information regarding why this occurs is limited. In this study, aged mouse kidneys displayed a reduced epithelial proliferative reserve in vivo and in vitro. Microarray analysis identified increased expression of zinc-alpha (2)-glycoprotein (Zag) in aged proximal tubular cells. The addition of recombinant Zag to pri...

discussion we have to stress that the importance of this case report is its presentation in an elderly patient, as the frequent age of presentation in the iranian patients is the middle age. on the other hand, pv occurs rarely, thus, the reporting of any rare case with some exceptions is important. case presentation we reported a case of pemphigus vulgaris in a 79-year-old patient with the exte...