there are some conflicts about constancy of conduction velocity (cv) in a given tract of nervous system. by recording excitatory postsynaptic currents (epsc) in layer iv of the somatosensory cortex we tried to clear changes in cv of thalamocortical tract of mice aged 3 to 50 days old. field potentials and epsc were recorded in the layer iv by stimulation of ventrobasal nucleus of thalamus (vb) ...

The combination of depression and anorexia may influence morbidity and progressive physical disability in the elderly. Gender differences exist in hypothalamic-pituitary-adrenal axis activation following stress exposure. The objective of this study was to investigate gender differences in feeding behavior under novelty stress in aged mice. Food intake measurement, immunohistochemical assessment...

Domeier TL, Roberts CJ, Gibson AK, Hanft LM, McDonald KS, Segal SS. Dantrolene suppresses spontaneous Ca release without altering excitation-contraction coupling in cardiomyocytes of aged mice. Am J Physiol Heart Circ Physiol 307: H818–H829, 2014. First published July 18, 2014; doi:10.1152/ajpheart.00287.2014.—Cardiac dysfunction in the aged heart reflects abnormalities in cardiomyocyte Ca home...

Abstract The number of central and peripheral B cells their responsiveness are decreased in aged mice. diversity mice cell repertoires with increasing age has not been elucidated. In this study, we demonstrated that there were significant differences the usage some V , D J genes BCR H-CDR3 repertoire bone marrow cells, spleen memory 3-, 12-, 20-month-old productive, pseudogene, out-of-frame seq...

BACKGROUND Hypoxic preconditioning of bone marrow cells (BMCs) from young healthy individuals can enhance the cells' therapeutic potential. Considering that the response to hypoxia may differ according to the quality of the cells, we assessed the effect of hypoxic preconditioning on BMCs from aged mice and compared the difference in response between BMCs from aged and young mice. METHODS AND ...

The aim of the present study was to evaluate the effect of a hydro-alcoholic extract of Vitex agnus-castus (VAC) fruit on blood urea nitrogen (BUN), creatinine (Cr) and, kidney histology of a female mouse model of D-galactose induced aging. In this experimental study, 72 NMRI mice were divided into 6 groups: control, VAC, D-galactose, D-galactose+VAC, aging, and aging+VAC. D-galactose was injec...