We have discovered that the bacterial toxins aerolysin and pertussis toxin share a common domain. This is surprising because the two toxins affect cells in very different ways. The common domain, which we call the APT domain, consists of two three-stranded antiparallel beta-sheets that come together and wrap around a central pair of helices. The APT domain shares a common fold with the C-type l...

The diarrheal mechanisms in Aeromonas enteritis are not completely understood. In this study we investigated the effect of aeromonads and of their secretory products on ion secretion and barrier function of monolayers of human intestinal cells (HT-29/B6). Ion secretion was determined as a short-circuit current (I(SC)) of HT-29/B6 monolayers mounted in Ussing-type chambers. Transepithelial resis...

Objective: To investigate the frequency of paroxysmal nocturnal hemoglobinuria (PNH), an acquired clonal hematopoietic stem cell disease resulting in complement-mediated hemolysis, patients with lymphoma by flow cytometry.Methods: Fifty who were admitted to hematology clinic, newly diagnosed and not yet treated included this study conducted 2014. The presence PNH clones was checked FLAER cytome...

We have investigated the presence of four virulence genes, i.e. alt, ast, aerolysin/hemolysin and lafA in 32 isolates of A. jandaei from clinical, environmental and animal origins. The lafA gene was the most widely distributed (61.5% of the isolates), followed by the aerolysin/hemolysin (42.3%), alt (11.5%) and ast (3.8%) genes. Only one human diarrhoeal isolate presented the ast gene in combin...

aeromonas hydrophila secretes several extracellular proteins including enterotoxin, hemolysin and aerolysin that are associated with the bacterial virulence. previous studies have shown that two hemolytic toxins, hemolysin a and aerolysin a contribute to the virulence of aeromonas hydrophila. in the current study, a total of 50 strains of aeromonas hydrophila, including 28 (56%) strains isolate...