It is unknown whether formoterol and salmeterol, two long-acting beta(2)-adrenoreceptor agonists, have regulatory functions in the production of T-helper cell (Th) type 2- and Th1-related chemokines by monocytes and bronchial epithelial cells. In the present study, the effects of formoterol and salmeterol on lipopolysaccharide (LPS)-induced expression of the Th2-related chemokine macrophage-der...

Letters to the Editor will be published, if suitable, as space permits. They should not exceed 1000 words (typed double-spaced) in length and may be subject to editing or abridgment. Agonistic autoantibodies directed against G protein– coupled receptors are implicated in the pathogenesis of various human cardiovascular disorders. A patient subset with idiopathic dilated cardiomyopathy features ...

Administration of salbutamol, a beta2-adrenoreceptor agonist, is associated with several metabolic consequences including disturbances of carbohydrate, lipid, and potassium homeostasis.5 Although the importance of these effects during therapeutic use of the drug is not clear, severe hypokalaemia has been reported after salbutamol poisoning.2 As evidence suggests that the metabolic effects are d...

benign prostatic hyperplasia generally affects males above fourty years of age and has significant effect in overall quality of life (qol). this is one of the cause of millions of dollors in healthcare expenditure. alpha one adrenoreceptor blockers are frequently used for the benign prostatic enlargement because of their significant effect on storage and voiding symptoms, qol, flow rate and pos...

Damron, Derek S., Noriaki Kanaya, Yasuyuki Homma, Si-Oh Kim, and Paul A. Murray. Role of PKC, tyrosine kinases, and Rho kinase in -adrenoreceptor-mediated PASM contraction. Am J Physiol Lung Cell Mol Physiol 283: L1051–L1064, 2002. First published July 12, 2002; 10.1152/ajplung.00345.2001.—Our objectives were to identify the relative contributions of intracellular free Ca2 concentration ([Ca2 ]...

The role of the sympathetic nervous system as it relates to adrenoreceptor-mediated hemodynamic responses was investigated in patients with essential hypertension and in normal subjects of similar age. An age-related increase in plasma norepinephrine (PNE) concentrations observed in 36 recumbent normal subjects (r = 0.623, p less than 0.001) was not found in 56 patients; the latter included som...

Whole cell voltage-clamp recordings were performed on auditory olivocochlear neurons in the ventral nucleus of the trapezoid body (VNTB) of brain stem slices from neonatal rats. Each neuron was identified by retrograde labeling with Fast Blue injected into the cochlea. Bath application of norepinephrine (NE; 1-10 microM) reversibly induced an inward current in 26 of 38 labeled neurons that were...