We develop candidate HIV-1 vaccines, of which two components, ChAdOx1.tHIVconsv1 (C1) and ChAdOx1.HIVconsv62 (C62), are delivered by the simian adenovirus-derived vaccine vector ChAdOx1. Aberrant adenovirus RNA splicing involving transgene(s) coding for SARS-CoV-2 spike was suggested as an aetiology rare adverse events temporarily associated with initial deployment adenovirus-vectored vaccines ...

background and aims: human adenoviruses can cause a diversity of clinical diseases, but there is no antiviral therapy formally approved by adenovirus infections. thus, antiviral agents derived from medicinal plants which are effective against adenoviruses infections are urgently required. therefore, this research was aimed to evaluate in vitro antiadenovirus activity of pomegranate (punica gran...

Coronavirus disease 2019 (COVID-19) vaccination is necessary to prevent infection, morbidity, and mortality. In addition the usual post-inoculation hypersensitivity reactions including headaches, muscle joint pain, fever, especially after second shot, mRNA vaccine has risk of inflammation in heart lining some recipients, mostly younger people. And adenovirus vector can induce rare immune thromb...

Background: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder. The precise etiology of this disease not clear, but some reports have indicated the role infectious agents in incidence disease. Objectives: Because potential viruses disease, study aimed to evaluate and compare frequency colonic adenovirus infection both IBS control subjects. Methods: Stool serum samples were...

background and aims: inclusion body hepatitis (ibh) is one of the most important reemerging diseases in many countries with intensive poultry industries. in iran, the etiological agent of ibh (fowl adenovirus) has not been yet confirmed. the aim of this study was the molecular detection and identification of fowl adenovirus involving ibh in chicken flocks in iran. materials and methods: polymer...

Salivirusis a new member of the familyPicornaviridaeand is associated with diarrhea, especially in children, being often found in feces. Here, we report the complete genome sequence of aSalivirusstrain in respiratory specimens from a child with adenovirus infection.

purpose: the main purpose of this study was to evaluate the prevalence of herpes simplex virus 1 and 2 (hsv-1 and hsv-2), varicella-zoster virus and adenovirus associated with conjunctivitis in swab samples of patients who referred to eye specialist hospitals in tehran. methods: in this cross-sectional study, swab samples from patients with acute conjunctivitis during the first sixth months of ...

During a 2014 measles outbreak in Vietnam, postmortem pathologic examination of hospitalized children who died showed that adenovirus type 7 pneumonia was a contributory cause of death in children with measles-associated immune suppression. Adenovirus type 7 pneumonia should be recognized as a major cause of secondary infection after measles.

Developing an effective anthrax vaccine that can induce a rapid and sustained immune response is a priority for the prevention of bioterrorism-associated anthrax infection. Here, we developed a recombinant replication-deficient adenovirus serotype 5-based vaccine expressing the humanized protective antigen (Ad5-PAopt). A single intramuscular injection of Ad5-PAopt resulted in rapid and robust h...

objective: e1a oncoprotein of adenovirus type 5 is a regulatory factor which controls transcription of other adenovirus genes. this protein promotes both viral genom replication and host cell transformation by altering the function of certain important cellular proteins such as p21 and rb. the aim of the present study was to constantly reduce the expression of e1a gene in hek 293 cell line by r...