NMR methods provide information about conformational dynamics of GPCRs over a wide range frequencies in aqueous media at near-physiological temperature, with minimal modification the wild-type GPCR covalent structures. Here we review our solution studies functionrelated GPCRs, including β2 adrenergic receptor, μ opioid and adenosine A2A receptor.

It is a well-established fact that adenosine and its receptor subtypes (A 1 and A ) are involved in changes of contractility, heart rate and coronary blood flow (CBF) under different circumstances. This study was conducted to evaluate the role of nitric oxide and prostaglandins in development of these changes. For this purpose, Nitro-L-Arginine methyl ester (L-NAME), and indomethacin as inhibit...

Our previous study demonstrated that an extract of Cordyceps militaris (CM) derived from Samia Cynthia ricini inhibits testosterone-induced prostate hypertrophy in animal model. However, the bioactive components CM modulate function cells have not been identified and characterized. To do this, present explored effective component(s) influences viability androgen-responsive LNCaP cancer androgen...

•m6A is an endogenous adenosine A3 receptor ligand with higher potency than •Extracellular m6A mainly stems from ribosomal RNA and mRNA •Cytotoxic stimulation induces release via lysosome-mediated catabolism facilitates allergy inflammation About 150 post-transcriptional modifications have been identified in all kingdoms of life. During catabolism, most modified nucleosides are resistant to deg...

The effects of intraperitoneal injection of N6-cyclohexyladenosine (CHA, a selective adenosine A1 receptor agonist) and 8-cyclopenthyle-I-3-dimethylexanthine (CPT, a selective adenosine A1 receptor antagonist) on entorhinal cortex-kindled seizures were investigated. Fully entorhinal cortex-kindled rats received normal saline (control), CHA (0.06, 0.12 and 0.25 mg/kg) or CPT (0.06 and 0.12 mg/kg...

In this study the effect of adenosine and caffeine on spontaneous activity of paragigantocellularis (PGi) neurons was investigated. The spontaneous activity of PGi neurons was significantly decreased by microinjection of adenosine (10 nM, 0.5 µl) into PGi nucleus of both control and morphine-dependent rats. The decrease in firing rate of PGi neurons of morphine-dependent rats was greater than t...

 ABSTRACT Background: The aims of this study were to assay the activity of adenosine deaminase (ADA) in estrogen receptor positive (MCF-7) and negative (MDA-MB468) breast cancer cell lines. Methods: MDA-MB468 and MCF-7 breast cancer cell lines were cultured in complete medium, striped serum with and without 0.0 1~-LM diethylstilbestrol (DES), complete medium in the presence and absence of 111M ...

in this study the effect of adenosine and caffeine on spontaneous activity of paragigantocellularis (pgi) neurons was investigated. the spontaneous activity of pgi neurons was significantly decreased by microinjection of adenosine (10 nm, 0.5 µl) into pgi nucleus of both control and morphine-dependent rats. the decrease in firing rate of pgi neurons of morphine-dependent rats was greater than t...

introduction:adenosine as a potent vasodilator has physiological role in regulation of regional cerebral blood flow (rcbf). metod: laser-dِoppler flowmetry technique was used to study pial vessels blood flow responses to adenosine receptors agonists and antagonist. male sprague dawley rats (250-350g) that were housed in standard conditions, were anesthetized with urethane (1.5g/kg). adenosine (g...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Li R, Jin S, He J, Peng Y, Wei L, Gu L. Exercise attenuates neuronal degeneration in Parkinson’s disease rat model by regulating the level of adenosine 2A receptor. Folia Neuropathologica. 2023. doi:10.5114/fn.2023.125120. APA Li, R., Jin, S., He, J., Peng, Y., Wei, L., & Gu, (2023). https://doi.org/10.5114/fn.202...