aims: cholera is an acute diarrheal disease that can lead to severe dehydration and death. antibiotic resistance is a big challenge in infective disease like cholera. the present study aimed to understand the characteristics and trends of antibiotic resistance of v. cholerae isolations in and around kashan, iran. instrument & methods: in this descriptive cross-sectional study, samples were gath...

The adamantane scaffold is found in several marketed drugs and in many investigational 11β-HSD1 inhibitors. Interestingly, all the clinically approved adamantane derivatives are C-1 substituted. We demonstrate that, in a series of paired adamantane isomers, substitution of the adamantane in C-2 is preferred over the substitution at C-1 and is necessary for potency at human 11β-HSD1. Furthermore...

A small-sized graphene oxide supramolecular assembly was obtained by the inclusion complexation of hyaluronated adamantane with β-cyclodextrin and the π-stacking of graphene oxide with camptothecin, exhibiting an excellent stability in the serum environment and a higher inhibition effect toward malignant cells than a free drug.

salmonella enterica is recognized as one of the major food-borne pathogens with more than 2,500 serotypesworldwide. the present study addresses antimicrobial resistance of salmonella enterica serovar enteritidisisolates in iran. a collection of 151 salmonella spp. isolates collected from poultry were serotyped toidentify salmonella enteritidis. sixty-one salmonella enteritidis were subsequently...

We have developed a straightforward method to prepare 1(st) and 2(nd) generation adamantane-based dendrons, previously called HYDRAmers, bearing at the periphery the anti-inflammatory drug, ibuprofen. The multivalency effect on the drug activity was studied, demonstrating that our multivalent ibuprofen-dendron conjugates exert an enhanced anti-inflammatory activity compared to free ibuprofen, i...

conclusions methicillin resistance is a specialized concern in clinical studies, and it is mandatory to detect this mechanism by an accurate method that is updated periodically. increasing the resistance of s. aureus to multiple antibiotics underlines the need for intermittent resistance surveillance. results methicillin resistance was detected in 38% of s. aureus isolates, confirmed by the aga...

tuberculosis is an infectious disease caused by mycobacterium tuberculosis and is the primary cause of mortality in the world. m. tuberculosis strains are important intracellular pathogens causing infection in oxygen-rich macrophages in the lungs. the emergence of aids, declined socioeconomic standards and a lessened emphasis on tb control programs have contributed to the disease resurgence. re...

background: nowadays, nosocomial infection with multidrug-resistant acinetobacter is an important problem in the world, which is facing wide spectrum antibiotics and hence has become resistant. m aterials and methods: in this study, positive cultures of acinetobacter from one hundred clinical samples in seven hospitals from tehran during 2012-2013 were collected for checking antibiotic suscepti...

background: due (drug utilization evaluation) studies can help identify and correct problems associated with irrational use of drugs. considering lack of data regarding how rational vancomycin is being used, we evaluated this due study in a referral infectious center to evaluate compliance with guidelines in terms of rational use of this valuable antibiotic. methods: this retrospective study wa...