CONTEXT Transfusion-related acute lung injury (TRALI) is a syndrome that includes dyspnea, hypotension, bilateral pulmonary edema, and fever. TRALI is the third leading cause of transfusion-related mortality, but it is probably underdiagnosed and underreported. OBJECTIVE To determine if blood products from a frequent plasma donor, whose blood product was implicated in a fatal case of TRALI, c...

PURPOSE To describe a case of transfusion-related acute lung injury (TRALI) after platelet transfusion immediately following cardiac surgery, and to review the clinical features, pathophysiology, management, and morbidity and mortality associated with such an event. CLINICAL FEATURES A 62-yr-old man was transferred to our centre for urgent coronary artery bypass grafting in the setting of rec...

BACKGROUND Transfusion services rely on transfusion reaction reporting to provide patient care and protect the blood supply. Unnecessary discontinuation of blood is a major wastage of scarce blood, as well as man, hours and funds. The aim of the present study was to describe the main characteristics of acute transfusion reactions reported in the 4 hospital of Kermanshah University of Medical Sc...

A hemolytic transfusion reaction (HTR) is the accelerated clearance or lysis of transfused red cells because of immunologic incompatibility. Although they may at times have similar clinical presentations, HTR is distinguished from autoimmune hemolysis or nonimmune causes of shortened survival of transfused red cells. HTR may occur when antigen-positive red cells are transfused to a patient with...

OBJECTIVE To receive and collate reports of death or major complications of transfusion of blood or components. DESIGN Haematologists were invited confidentially to report deaths and major complications after blood transfusion during October 1996 to September 1998. SETTING Hospitals in United Kingdom and Ireland. SUBJECTS Patients who died or experienced serious complications, as defined ...

A llergic transfusion reactions (ATRs) and febrile nonhemolytic transfusion reactions (FNHTRs) have plagued the administration of blood since the early 20th century. One of the first reports of an ATR was in 1919. Ramirez documented a patient with no underlying allergies, asthma, or bronchitis who developed bronchial asthma to horse dandruff within 2 weeks of receiving a 600-mL blood transfusio...