background: recurrent herpes labialis (rhl) is one of most common infective vesiculoulcerative lesions. according to some studies administration of topical and/or systemic zinc compositions has been effective in treatment and prevention. this article aims to comparison of zinc level in healthy subjects and rhl patients in acute and convalescent phases. materials and methods: this was a retrospe...

Objective(s) Sickle cell disease is a genetic disorder characterized by chronic haemolytic anaemia. Haemoglobin S containing red blood cells may be susceptible to oxidative stress due to imbalance between production of reactive oxygen species and the countering effect of the various antioxidants present in the body. Materials and Methods We evaluated some antioxidant enzymes which include gl...

Acute phase proteins (APPs) are important diagnostic indicators of inflammatory disturbances in animals. The objectives of the current study were to validate analytical methods for measuring haptoglobin (Hp), serum amyloid A (SAA), acid soluble glycoprotein (ASG), fibrinogen, and albumin concentrations in goats and to evaluate their response to an inflammatory stimulus in this species. Intra- a...

Bernheimer and Cantoni (1), in 1947, described an unusual "anti toxic" mechanism in mice, characterized by the development of a temporary state of resistance to the lethal effect of streptolysin O within hours of the intravenous administration of sublethal amounts of this toxin. Rowen and Bemheimer (2) subsequently found this induced refractoriness to be associated with an increased capacity of...

The origin of soluble CD14 (sCD14) in the circulation is uncertain. To examine whether CD14 could be an acute-phase protein (APP), the levels of sCD14, IL-6, and C-reactive protein were determined by ELISA in serum and synovial fluid (SF) of patients with various arthropathies, and the regulation of CD14 synthesis was examined in liver cells. In patients with crystal-mediated or immunologically...

Inflammation is an adaptive mechanism to insure restoration of tissue and cell homeostasis after injury, infection or stress. The inflammatory response leads to differential recruitment of immune cells in organs, as well as cell-specific modifications by inflammation-induced signaling pathways. All these inflammatory-specific changes establish celland lineage-context dependent gene expression p...

Regulation of C4b-binding protein (C4BP) isoforms during acute phase and its relationship to the plasma concentration of free protein S was elucidated. An assay for beta chain containing C4BP (C4BP beta+) was developed and the concentrations of total C4BP, C4BP beta+, total, free, and bound protein S were measured in patients with acute-phase response. Even though total C4BP was increased to 16...

Introduction: Elevated levels of CRP are present among patients at risk for further first-ever myocardial infarction and stroke. It has been shown that after ischemic stroke, increased levels of CRP are associated with unfavorable outcomes. Methods: From 120 patients admitted to the emergency unit of our hospital with the diagnosis of stroke CRP, D-dimer and ferritin level was measured and the ...