Acute necrotizing encephalopathy (ANE) is a rare but distinctive type of acute encephalopathy with global distribution. Occurrence of ANE is usually preceded by a virus-associated febrile illness and ensued by rapid deterioration. However, the causal relationship between viral infections and ANE and the exact pathogenesis of ANE remain unclear; both environmental and host factors might be invol...

Background: During the COVID-19 pandemic, besides the most prevalent respiratory and systemic symptoms, some neurological symptoms such as acute hemorrhagic necrotizing encephalopathy and myelitis associated with COVID-19 have been reported. It is suspected that COVID-19 involves different body systems via interaction with the ACE-2 (angiotensin-converting enzyme 2) receptor. As ACE2 is express...

acute gastroenteritis (age) is a serious disease and is one of the most important causes of early childhood mortality in developing countries. the neurologic manifestations can be propounded as primary symptoms of age. in order to determine the rate, clinical presentations, and outcome of patients with age who presented with neurologic manifestations and compare them with patients without neuro...

Acute necrotizing encephalopathy (ANE) is influenza-associated (IAE) that mostly occurs in younger age groups following an acute viral illness with a very low recovery rate. It rare but rapidly progressive neurodegenerative disorder which pathogenesis still not clear. There are some cases reported where the virus can directly invade central nervous system (CNS) through peripheral system. Severa...

background and aim: neonatal jaundice is one of the common causes of early sensori­neural hearing loss and an important cause of deafness in children. auditory responses are the most sensitive parts of the nervous system to the toxic effect of bilirubin. this study was aimed to examine the effect of neonatal hyperbili­rubinemia and its treatment on auditory brain­stem responses (abr). methods: ...

We identified a novel mink orthoreovirus, MRV1HB-A, which seems to be closely related to human strain MRV2tou05, which was isolated from 2 children with acute necrotizing encephalopathy in 2005. Evolution of this virus should be closely monitored so that prevention and control measures can be taken should it become more virulent.