OBJECTIVE The objective was to evaluate the relationships between all types of fetal fatty acid oxidation defects and maternal liver disease, including acute fatty liver of pregnancy and hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome. METHODS This was a case-control study comparing fetal fatty acid oxidation defects to the outcome of maternal liver disease. Fifty case i...

ed from the database of PubMed (1979 – December 2012) using the search 67 terms including “acute fatty liver of pregnancy”, “HELLP syndrome”, and “liver 68 AFLP and HELLP syndrome 5 dysfunction in pregnancy”. English literatures cited in these reports were also 69

This chapter summarizes the clinical presentation, pathophysiology, evaluation and management of six commonly encountered complications unique to pregnancy that require critical care management: obstetric haemorrhage; pre-eclampsia/HELLP (haemolysis-elevated liver enzymes-low platelets) syndrome; acute fatty liver of pregnancy; peripartum cardiomyopathy; amniotic fluid embolism; and trauma.

Pregnancy is associated with altered liver function, particularly in serum enzymes. Anabolic steroids are responsible to some degree in mediating the physiologic and biochemical changes that occur during an uncomplicated pregnancy. However, several liver disorders are unique to pregnancy and include intrahepatic cholestasis of pregnancy, acute fatty liver of pregnancy, and hepatic dysfunction a...

Acute fatty liver of pregnancy (AFLP) is a rare and potentially fatal disease that occurs in the 3<sup>rd</sup> trimester pregnancy. This article presents two clinical cases AFLP provides review literature on this pathology. Diagnosis based clinical, laboratory radiological criteria, treatment involves early recognition condition with delivery full supportive maternal care are extre...