acute leukemia is the most common malignancy in childhood, which mainly involves children less than 15 years of age. the growing skeleton is the main site of involvement in children. leukemic cells proliferate within the massive red bone marrow in children. so besides the pallor, petechia, purpura and ecchymosis in the skin and mucosal surfaces, bone pain and other bony lesions are other manife...

Twenty-one patients with acute bone pain in areas other than the scaphoid were referred for isotope bone imaging directly from the A&E department. Of these scans 61% were positive. The various pathologies seen included stress fractures, osteomyelitis and bony metastases. Implications of the findings are discussed.

introduction: the aim of the present study was to evaluate the efficacy and safety profile of bone palliative therapy following administration of 153sm-edtmp in patients with intractable metastatic bone pain. methods: sixteen patients (9 male, 7 female) aged 29-80 years (57.3±16.7 years) with severe metastasis-related bone pain resistant to analgesic medications were enrolled in the study. all...

introduction: the selective medication for pain control in many clinical situations is morphine but its complications prevent its widespread use. ketamine has been introduced as an alternative for morphine in some studies. however, the efficacy of its solitary use has not yet been evaluated. therefore, the present study was undertaken to evaluate the effect of ketamine alone in relieving pain i...

Prostate cancer is unique in that bone is often the only clinically detectable site of metastasis. Prostate tumors that have metastasized to bone frequently induce bone pain which can be difficult to fully control as it seems to be driven simultaneously by inflammatory, neuropathic, and tumorigenic mechanisms. As nerve growth factor (NGF) has been shown to modulate inflammatory and some neuropa...

background: low back pain (lbp) is one of the most common musculoskeletal complications of today’s societies which, poses a big portion of health expenses and work absentees. lumbar disc herniation is claimed to be one of the several causes of lbp. conservative therapies like physiotherapy are found to be beneficial for treatment in such a kind of lbp. however, there is low evidence proving tra...

results of all 93 assessed children (52 male, 41 female) with mean age 6.45 y/o, 18 cases (19.4%) had abnormal renal parenchymal echogenicity (equal or more than liver).the final diagnosis of the cause of abdominal pain in 43 cases (46.2%) was acute appendicitis, in 8 cases (8.6%) was mesenteric adenitis, in 4 cases (4.3%) was gastroenteritis and in 2 cases (2.2%) was invagination. conclusions ...

Many cancerous solid tumors metastasize to the bone and induce pain (cancer-induced bone pain [CIBP]). Cancer-induced bone pain is often severe because of enhanced inflammation, rapid bone degradation, and disease progression. Opioids are prescribed to manage this pain, but they may enhance bone loss and increase tumor proliferation, further compromising patient quality of life. Angiotensin-(1-...

More than half of all chronic cancer pain arises from metastases to bone, and bone cancer pain is one of the most difficult of all persistent pain states to fully control. Several tumor types including sarcomas and breast, prostate, and lung carcinomas grow in or preferentially metastasize to the skeleton where they proliferate, and induce significant bone remodeling, bone destruction, and canc...

introduction: bone metastases are the most common cause of cancer-related pain in various primary malignant tumors, most often, breast and prostate. 188re-hydroxyethylidene diphosphonate (188re-hedp) is a new and less expensive bone seeking radiopharmaceutical with favorable physical characteristics of the radionuclide such as short half life of 16.9h, maximal β energy of 2.1 mev with a 15% γ-c...