نتایج جستجو برای: activin a

تعداد نتایج: 13432651  

Journal: :Journal of applied physiology 2009
Arne Yndestad Karl-Otto Larsen Erik Oie Thor Ueland Camilla Smith Bente Halvorsen Ivar Sjaastad Ole Henning Skjønsberg Turid M Pedersen Ole-Gunnar Anfinsen Jan Kristian Damås Geir Christensen Pål Aukrust Arne K Andreassen

Activin A, a member of the transforming growth factor (TGF)-beta superfamily, is involved in regulation of tissue remodeling and inflammation. Herein, we wanted to explore a role for activin A in pulmonary hypertension (PH). Circulating levels of activin A and its binding protein follistatin were measured in patients with PH (n = 47) and control subjects (n = 14). To investigate synthesis and l...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
Antonia L Dow David S Russell Ronald S Duman

Activin is a member of the transforming growth factor-beta family that is involved in cell differentiation, hormone secretion, and regulation of neuron survival. The cellular responses to activin are mediated by phosphorylation of a downstream target, Smad2. The current study examines the influence of chronic electroconvulsive seizures (ECSs), as well as chemical antidepressants, on the express...

Journal: :Mechanisms of Development 1995
Olli Ritvos Timo Tuuri Marja Erämaa Kirsi Sainio Kristiina Hildén Lauri Saxén Scott F. Gilbert

We report that activin profoundly alters epithelial branching morphogenesis of embryonic mouse salivary gland, pancreas and kidney rudiments in culture, indicating that it may play a role as a morphogen during mammalian organogenesis. In developing pancreas and salivary gland rudiments, activin causes severe disruption of normal lobulation patterns of the epithelium whereas follistatin, an acti...

Journal: :The Journal of clinical investigation 1993
H Yasuda T Mine H Shibata Y Eto Y Hasegawa T Takeuchi S Asano I Kojima

The present study was conducted to examine the effect of activin A on growth of rat hepatocytes. EGF induced a 10-fold increase in DNA synthesis as assessed by [3H]thymidine incorporation in cultured hepatocytes. When activin A was added together with EGF, DNA synthesis induced by EGF was markedly inhibited. Inhibition was detected at a concentration of 10(-10) M, and 5 x 10(-9) M activin A alm...

Journal: :Human reproduction 2006
F Debiève L Hinck J-M Biard P Bernard C Hubinont

BACKGROUND Apoptosis, a process of normal embryonic development, is enhanced in blastocyst from diabetic rats. Nevertheless, glucose seems not to be the only factor involved. Activin A, a TGF-beta family member, is also increased in maternal serum from diabetic pregnancy. METHODS Flushing medium, blastocysts and uterine cells were obtained from 5 day old pregnant rats. The presence of activin...

2017
Yan Qi Jingyan Ge Chunhui Ma Na Wu Xueling Cui Zhonghui Liu

Activin A, a member of the transforming growth factor beta superfamily, acts as a pro-inflammatory factor in acute phase response, and influences the pathological progress of neutrophil-mediated disease. However, whether activin A can exert an effect on the activities of neutrophils remains unclear. In this study, we found that the release of activin A was enhanced from neutrophils of mouse whe...

2017
Roger S K Fung Jin Bai Karen W Y Yuen Anderson O L Wong

Gonadotrophin regulation by activin/follistatin system is well-documented, but the corresponding effect on growth hormone (GH) has not been fully characterized and with little information available in lower vertebrates, especially in fish models. In grass carp, local interactions of GH and luteinizing hormone (LH) can induce GH release and gene expression at pituitary level via autocrine/paracr...

Journal: :European cytokine network 2008
Sara Scutera Elena Riboldi Roberta Daniele Angela Rita Elia Tiziana Fraone Carlotta Castagnoli Mirella Giovarelli Tiziana Musso Silvano Sozzani

Activin A, a member of the transforming growth factor-beta superfamily, has a role in tissue repair and inflammation. In our previous studies, we identified by immunohistochemistry DC-SIGN(+) dendritic cells as a source of activin A in vivo. The present study was aimed at investigating activin A production by dendritic cells (DC) in vitro and its function. Here we demonstrate that monocyte-deri...

2017
Miao Liu Cuiying Mao Jiayu Li Fanglei Han Ping Yang

BACKGROUND A previous study suggested that activin A inhibited myocardial cell apoptosis. This study thus aimed to explore the effects of the activin A-follistatin system on myocardial cell apoptosis in heart failure (HF) rats in order to determine whether or not the mechanism operates through the endoplasmic reticulum stress (ERS) pathway. METHODS Myocardial infarction (MI) by vascular depri...

Journal: :American journal of physiology. Cell physiology 2007
Anandaroop Mukhopadhyay Sui Yung Chan Ivor J Lim David J Phillips Thang T Phan

Keloid scars represent a pathological response to cutaneous injury under the regulation of many growth factors. Activin-A, a dimeric protein and a member of the transforming growth factor-beta superfamily, has been shown to regulate various aspects of cell growth and differentiation in the repair of the skin mesenchyme and the epidermis. Thus our aim was to study the role of activin and its ant...

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