S moking has been well recognised as the main cause of lung cancer, chronic obstructive pulmonary disease, peripheral atherosclerosis, and as one of the most important risk factors for cardiovascular disease. One should keep in mind that tobacco smoke contains over 400 chemicals, more than 60 of which are known or suspected to be carcinogenic. Tobacco smoke also contains carbon monoxide, a pois...

introduction: cigarette smoking affects nitric oxide production. the aim of this study was to determine associations between tobacco smoke and serum nitric oxide metabolites (nox) concentration. methods: serum nox concentration was measured by the griess method in 230 nonsmokers, 238 active, 196 passive and 29 waterpipe smokers. subjects were selected from participants of tehran lipid and gluco...

OBJECTIVES Cotinine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) are widely used biomarkers for tobacco-derived nicotine and the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), respectively. The discrepancy between cotinine levels in relation to disease risk comparing active versus passive smoking suggests a nonlinear tobacco smoke dose-response and/or that cot...

BACKGROUND Polymorphisms in the N-acetyltransferase 2 (NAT2) gene influence the rate of metabolism of aromatic and heterocyclic amines present in tobacco smoke. Because the physicochemical composition of mainstream and sidestream smoke differ, we conducted a case-control study to assess a possible differential effect of NAT2 genotype on the relationship between active/passive smoke exposure and...

spring summer 2010, vol.4, no.1 /74 medical laboratory journal severity of oxidative dna damage in gastric tissue of smoker and non-smoker patients with dyspepsia abstract background and objectives: cigarette smoking is associated with an increase in risk of peptic ulcer and gastro-intestinal cancer. toxic materials in smoke and tar have a significant role in production of carcinogenic complexe...

background one of the requirements of the osun state smoke-free legislation is to ensure smoke-free enclosed and partially enclosed workplaces. this survey was conducted to assess the knowledge and attitude of workers in indoor bars, beer parlors and discotheques to smoke-free legislation in general and the osun state smoke-free law in particular.   methods a convenience sampling of 36 hospital...

The incidence of urban female breast cancer has been continuously increasing over the past decade with unknown etiology. One hypothesis for this increase is carcinogen exposure from tobacco. Therefore, the objective of this study was to investigate the risk of urban female breast cancer from tobacco smoke exposure. The matched case control study was conducted among Thai females, aged 17-76 year...

This article reviews data from experimental and epidemiologic studies on passive smoking and makes 12 recommendations for further study. The physicochemical nature of passive smoke, the smoke inhaled by nonsmokers, differs significantly from the mainstream smoke inhaled by the active smoker. At present, measurement of urinary cotinine appears to be the best method of assessing exposures to pass...