platelet activating factor (paf) is a novel signaling phospholipids that in addition to platelet activation has many biological properties. the acrosome reaction, as an essential step in mammalian fertilization, can occur in response to several agents such as paf. therefore, the present study aimed to assess the effect of paf on the motility and acrosome reaction of ram spermatozoa. semen was c...

Economic welding of thick steel plates is an emerging challenge for various engineering applications. However, tungsten inert gas (TIG) arc welding, as economic and widely used method, not regarded a suitable tool to weld due the shallow penetration in single-pass operation. In this technical progress, joining austenitic high manganese 8 mm thickness was successfully performed using nanowire fl...

gas tungsten arc welding is a popular process in those applications requiring a high degree of quality andaccuracy. however, this process has a big disadvantage against the substantially high productivity weldingprocedures. hence, many efforts have been made to improve its productivity. one of these efforts is the use of activating flux (a-tig welding). in this study, the performance of a-tig w...

316L stainless steel joined to mild is widespread in several applications reach a requested good association of mechanical properties at lower cost. The activating tungsten inert gas (ATIG) weld was carried out using modified flux composed 76.63% SiO2 + 13.37% Cr2O3 10% NaF meet standard recommendations terms limiting the root penetration. Modified optimal gave depth penetration 1.84 times grea...

This paper proposes a mechanism responsible for setting the sustainable level of muscle performance. Our contentions are that the sustainable work rate is determined (i) at the muscle level, (ii) by the ability to maintain ATP supply and (iii) by the products of glycolysis that may inhibit the signal for oxidative phosphorylation. We argue below that no single factor 'limits' sustainable perfor...

Epigallocatechin gallate (EGCG) is a major polyphenol in green tea. Recent studies have reported that EGCG can inhibit TRAIL-induced apoptosis and activate autophagic flux in cancer cells. However, the mechanism behind these processes is unclear. The present study found that EGCG prevents tumor cell death by antagonizing the TRAIL pathway and activating autophagy flux. Our results indicate that...

Leukocyte trafficking to acute sites of injury or infection requires spatial and temporal cues that fine tune precise sites of firm adhesion and guide migration to endothelial junctions where they undergo diapedesis to sites of insult. Many detailed studies on the location and gradient of chemokines such as IL-8 and other CXCR ligands reveal that their recognition shortly after selectin-mediate...