Nomenclature for the chemerin receptors is presented as recommended by NC-IUPHAR [15, 44]). The chemoattractant protein and adipokine, chemerin, has been shown to be endogenous ligand both family receptors. Chemerin1 was founding member, when GPR1 de-orphanised it re-named Chermerin2 [44]. also activated lipid-derived, anti-inflammatory resolvin E1 (RvE1), which formed via sequential metabolism...

allergic rhinitis  (ar) is  an  inflammatory  disorder  of  the  nasal  mucosa  with  high morbidity and prevalence. natural killer (nk) cells might have a role in ar. we aimed to evaluate the changes of the markers and receptors on nk cells in ar patients compared to the non-atopic controls. flow  cytometric  analysis was  used  with  double  staining  of  the  peripheral  blood mononuclear ce...

introduction: the neuroprotective role of opioid morphine against 6-hydroxydopamineinduced cell death has been demonstrated. however, the exact mechanism(s) underlying such neuroprotection, especially the role of subtype receptors, has not yet been fully clarified. methods: here, we investigated the effects of different opioid agonists on 6-ohda-induced neurotoxicity in human neuroblastoma sh-s...

Pharmaconutrition is an area of current interest, especially concerning the advances in pharmacology nutrient-sensing receptors, as have been accomplished last 20 years. The family free fatty acid (FFA) receptors composed four members, sequentially named FFA1 to FFA4, which are activated by short long-chain acids. affinity and FFA4 for omega-3 polyunsaturated acids prompted pre-clinical clinica...

Systemic sclerosis (SSc) is an idiopathic autoimmune disease with a heterogeneous clinical phenotype ranging from limited cutaneous involvement to rapidly progressive diffuse SSc. The most severe SSc and pathologic manifestations result uncontrolled fibrotic process involving the skin various internal organs. molecular mechanisms responsible for initiation progression of have not been fully elu...