Dendritic cells (DCs) are the most potent antigen-presenting cells. Upon maturation, DCs express costimulatory molecules and migrate to lymph nodes present antigens T The actin cytoskeleton plays key roles in multiple aspects of DC functions. However, little is known about mechanisms identities actin-binding proteins that control maturation maturation-associated functional changes. Tropomodulin...

Formins are actin polymerization factors that are known to nucleate and elongate actin filaments at the barbed end. In the present study we show that human FHOD1 lacks actin nucleation and elongation capacity, but acts as an actin bundling factor with capping activity toward the filament barbed end. Constitutively active FHOD1 associates with actin filaments in filopodia and lamellipodia at the...

  Background and Objective: Inflammatory pseudotumor  is a lesion composed of proliferating spindle cells with mixed inflammatory infiltrates. Some authors have proposed the name inflammatory myofibroblastic tumor as a proper descriptive term rather than the vague inflammatory pseudotumor. The aim of this study was to verify the myofibroblastic origin of spindle cells in idiopathic orbital inf...

The number of actin binding proteins for which (part of) the three-dimensional structure is known, is steadily increasing. This has led to a picture in which defined structural modules with actin binding capacity are shared between different actin binding proteins. A classification of these based on their common three-dimensional modules appears a logical future step and in this review we provi...

13 cases of  gastrointestinal stromal tumors (GIST) diagnosed in Kerman university hospitals between 1370-1376 are reviewed.of these cases,6 were male and 7 were female.patients, age ranged between 19 to 70 years with a median of 47.8 years. in 8 cases tumor developed in stomach and in 5 cases it originated from small intestine.all available H & E stained slides were reviewed and PAS and masson...

Background: CAPZA3 is one of the actin-capping proteins believed to be play an important role in controlling of actin polymerization during spermiogenesis and has been shown to be peresent in mature sperm. Immunohistochemistry showed that human CAPZA3 is localized in the neck region of ejaculated sperm, with moderate and faint signals also detected in the tail and post-acrosome region respectiv...

In the published article, images for Actin in Figs. 4a, 5a, 6a, and 6c were incorrectly presented.

In the presence of deuterium oxide actin filaments in entangled networks align to form thick bundles.

As metastasis is responsible for most cancer-related deaths, understanding the cellular and molecular events that lead to cancer cell migration invasion will certainly provide insights into novel anti-metastatic therapeutic targets. Fascin-1 an actin-bundling protein fundamental all physiological or pathological processes require migration. It cross-linking actin microfilaments during formation...