Previous preclinical studies with ectopic tumor models have demonstrated remarkable improvements in the therapeutic profile of paclitaxel, formulated as a copolymer with poly-L-glutamic acid, compared with paclitaxel in the clinical formulation, Taxol. In this study, we evaluated these formulations in two human ovarian carcinoma xenograft models, NMP-1 and HEY, in nude mice. i.p. implantation i...

The electrochemical properties of a solid polymer electrolyte consisting of a diblock copolymer and lithium bis oxalato borate, LiBC4O8 LiBOB salt, is reported. The spherical microphase-separated diblock copolymer is composed of a majority poly ethylene oxide PEO block and a minority random copolymer block of methyl methacrylate MMA and lithium salt of methacrylic acid MAALi , PEO-bPMMA-ran-PMA...

The ability of some microorganisms to use lactic acid stereocopolymers and copolymers with glycolic acid as sole carbon and energy sources was studied under controlled or natural conditions. First, 14 filamentous fungal strains were tested in liquid cultures, adopting total lactic acid consumption, nitrogen source exhaustion, and maximal biomass production as selection criteria. Two strains of ...

The design of novel binder systems is required for the high capacity silicon (Si) anodes which usually undergo huge volume change during the charge/discharge cycling. Here, we introduce a poly (acrylic acid sodium)-grafted-carboxymethyl cellulose (NaPAA-g-CMC) copolymer as an excellent binder for Si anode in lithium ion batteries (LIBs). The NaPAA-g-CMC copolymer was prepared via a free radical...

In this paper, we have investigated the lower critical solution temperature (LCST) of N-isopropylacrylamide-acrylic acid (NIPAAm-AAc) copolymer as a function of chain-transfer agent/initiator mole ratio, acrylic acid content of copolymer, concentration, pH and ionic strength of aqueous copolymer solution. Aqueous solutions with the desired properties were prepared from previously purified polym...

We developed nanospheres of crosslinked networks of methacrylic acid grafted with poly(ethylene glycol), and acrylic acid grafted with poly(ethylene glycol) nanospheres for use as oral insulin delivery devices. The copolymer nanospheres were synthesized via free-radical precipitation/dispersion. The average particle diameter of the copolymer gel nanospheres at various physiologically relevant p...

Present research is a preliminary report on the novel pH-responsive micelles based on an amphiphilic brush copolymer P(PEGMA)-b-P(DMAEMA-co-CPLAMA) used as the promising drug carrier. The copolymer was synthesized using cholesteryl poly(L-lactic acid) methacrylate (CPLAMA), poly(ethylene glycol) monomethyl ether methacrylate (PEGMA) and 2-(dimethylamino)ethyl methacrylate (DMAEMA) with appropri...

The extraction of cellulose from sisal fiber was done initially using the steam explosion method. Extracted cellulose was grafted with acrylic acid in the presence of ceric ammonium nitrate redox initiator. The grafting phenomenon taking place between cellulose and the acrylic acid was proved by Fourier transform infrared spectroscopy (FTIR). The prepared graft copolymer was used as adsorbent f...

Lansoprazole fast-disintegrating tablet (LFDT) is a new patient-friendly formulation of lansoprazole. Since lansoprazole is an antiulcer agent and is unstable under acidic conditions, we have developed LFDT as an orally disintegrating tablet containing enteric-coated microgranules. The effect of compression on dissolution behavior was investigated, as compression affected cleavage and crushing ...

Unusual solvent responsive wettability of water-induced superhydrophobicity was realized on a smart copolymer surface containing double amino acid units.