Aconitum carmichaelii is an important medicinal herb used widely in China, Japan, India, Korea, and other Asian countries. While extensive research on the characterization of metabolic extracts of A. carmichaelii has shown accumulation of numerous bioactive metabolites including aconitine and aconitine-type diterpene alkaloids, its biosynthetic pathway remains largely unknown. Biosynthesis of t...

The roots from Aconitum sp. plants have long been used in Chinese herbal medicine for treating pain and various heart conditions. The principal component of Aconitum remedies is usually aconitine, a site 2 neurotoxin that may induce severe neurological symptoms and cardiovascular collapse. Some Aconitum species also contain lappaconitine, the structure of which is remarkably similar to that of ...

Renewed interest in the pharmacological action of aconitine has followed the work of Sherf (1947), Prinzmetal et al. (1950 and 1951), and Brown and Acheson (1952). Its use in experimental medicine produces stimulus formation in the dog's heart with auricular tachycardia and in certain circumstances ventricular tachycardia and fibrillation: it has become a useful tool in the hands of the researc...

in this study, it was surveyed to know whether an oral single dose of oleuropein could mimic the cardiac preconditioning in rats’ hearts or whether its prolonged oral administration could protect the heart against the aconitine-induced arrhythmia in rats. eighty male wistar rats were divided into two series (n = 8 in each group). in the first series, all groups (except the control (con) group) ...

Hydrogen and some divalent cations block Na channels in a voltage-dependent manner (Woodhull 1973; Ulbricht and Wagner 1975; Mozhayeva et al. 1981, 1982a; Begenisich and Danko 1983). The potential-dependence of this blockage suggests that the binding site for blocking ions is situated in the pore at some fractional distance (<5) from the outside (Woodhull 1973). Alkaloid aconitine has been show...