A selection of cyclic and acyclic acetylenic scaffolds bearing two tetrathiafulvalene (TTF) units was prepared by different metal-catalyzed coupling reactions. The bridge separating the two TTF units was systematically changed from linearly conjugated ethyne, butadiyne and tetraethynylethene (trans-substituted) units to a cross-conjugated tetraethynylethene unit, placed in either acyclic or cyc...

Biosynthesis of prostaglandins could be stopped by several acetylenic acids. They interfered with the oxygenase activity of the sheep vesicular gland enzymic system in two distinct patterns: an instantaneous, concentration-dependent effect and a time-dependent, destructive effect. Constants for both effects are reported. No measurable oxygen consumption tias observed with the acetylenic analogs...

Terminal acetylenic fatty acid mechanism-based inhibitors (Ortiz de Montellano, P. R., and Reich, N. O. (1984) J. Biol. Chem. 259, 4136-4141) were used as probes in determining the substrate specificity of rabbit lung cytochrome P-450 isozymes of pregnant animals in both microsomes and reconstituted systems. Lung microsomal and reconstituted P-450 form 5-catalyzed lauric acid omega- and (omega-...

Substituting olefinic for acetylenic pi-spacers in anthracene-based conjugated semiconductor donors leads to appreciable increases in the power conversion efficiencies of the resulting bulk heterojunction solar cells.

cule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1), play a pivotal role in the inflammatory and immunological responses. They are initially upregulated on the endothelium by tumor necrosis factor-a (TNF-a) or interleukin-1 (IL-1) and go on to mediate the steps of leukocyte migration from the vasculature into the inflamed tissue, these leukocytes then promote the inflamma...

Marine-derived compounds have been explored and considered as possible antitumor agents. In this study, we analyzed extracts of the sponge Cribrochalina vasculum for their ability to inhibit tumor cell proliferation. Screening identified two acetylenic compounds of similar structure that showed strong tumor-specific toxicity in non-small cell lung carcinoma (NSCLC) cells and small-cell lung car...

Mouse brain glutamate decarboxylase(s) was specifically titrated in vivo and in crude brain homogenates by a combination of gabaculine and [a-'H]acetylenic yaminobutyric acid. This specific titration is based on the differential spectra of action of these two mechanism-based enzyme inactivators. The specificity of the titration in vitro was demonstrated by showing that the time course of radioa...