BACKGROUND AND PURPOSE Evidence exists in support of a role of genetic factors in susceptibility to aneurysmal subarachnoid hemorrhage (SAH) in humans. Meta-analysis of 2 previous studies showed that the I allele of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism was a weak, but significant, risk factor for aneurysmal SAH. Moreover, a recent study has shown that t...

An insertion/deletion (IID) polymorphism of the angiotensin converting enzyme (ACE) gene is associated with plasma ACE levels in white populations. The occurrence ofthe I/D polymorphism and relationship to ACE levels was examined in a Pima Indian group (n=305). The frequency of the D allele was lower in Pimas than whites (0-29 v 0-52 respectively). ACE levels were significantly associated with ...

Some studies have reported that angiotensin converting enzyme (ACE) and angiotensinogen (AGT) genes have been associated with hypertrophic cardiomyopathy (HCM). However, there have been inconsonant results among different studies. To clarify the influence of ACE and AGT on HCM, a systemic review and meta-analysis of case-control studies were performed. The following databases were searched to i...

Stroke is a multifactorial disease in which genetic factors play an important role. This study was carried out to determine angiotensin-converting enzyme (ACE) gene polymorphism in Turkish acute stroke patients and to establish whether there is an association of angiotensin-converting enzyme gene I/D polymorphism with clinical parameters. In this study 185 patients and 50 controls were recruite...

Angiotensin II is the major effector molecule of renin-angiotensin system; its production can be conveniently interrupted by angiotensin-converting enzyme (ACE). Typical plasma levels of ACE accompany the I/D polymorphism; however, a controversy exists as to whether the DD genotype of the ACE polymorphism affects the risk for the development of coronary artery disease (CAD) and to what extent t...

Great personal enthusiasm, temptation, technical efforts, and complex mathematical equations characterize the developing research field of newly identified gene polymorphisms and their impact on a variety of cardiovascular diseases. After the first publication of Cambien and coworkers1 in Nature in 1992, who reported that the D/D angiotensinconverting enzyme (ACE) polymorphism is a potent risk ...

The angiotensin-converting enzyme (ACE) gene consists of 26 exons, it is located on chromosome 17 and its polymorphism a major contributing factor to hypertension. aim compare the efficacy Chlorthalidone Azilsartan in newly diagnosed hypertension patients association with ACE polymorphism. study was conducted department pharmacology, Rama medical college, Kanpur. After doing genetic test basic ...

The association between the polymorphism of the angiotensin-converting enzyme (ACE) gene and breast cancer risk has been extensively studied, however , the studies about the prognostic factors and ACE gene polymorphism are limited in number. Our aims were to analyze the distribution of the insertion/deletion (I/D) polymor-phism of the ACE gene in Turkish premenopausal patients with breast cance...

Angiotensin converting enzyme (ACE) plays an essential role in two physiological systems, one leading to the production of angiotensin II and the other to the degradation of bradykinin. The wide distribution and multifunctional properties of these peptides suggest that ACE could be involved in various pathophysiological conditions. The discovery that ACE levels are under genetic control ushered...

Angiotensin converting enzyme (ACE) is thought to influence susceptibility, disease progression, and/or outcome of sarcoidosis by functional mutations/polymorphisms of the ACE gene, such as the ACE gene deletion/insertion (D/I) polymorphism or the angiotensin receptors like the angiotensin II receptor type 1 (AT2R1) A1166 --> C polymorphism. The aim of our study was to examine the distribution ...