BACKGROUND Hepatitis B virus (HBV) DNA sequence data from thousands of samples are present in the public sequence databases. No publicly available, up-to-date, multiple sequence alignments, containing full-length and subgenomic fragments per genotype, are available. Such alignments are useful in many analysis applications, including data-mining and phylogenetic analyses. RESULTS By issuing a ...

This paper presents a Web-based environment for visualizing, editing and evaluating multiple ontology alignments. Users can configure their environment according to their needs and tasks, choosing different visualization modes and creating different profiles. They can apply a set of operations on the alignments (filtering, merge, etc.) and evaluate them against a reference one, using classical ...

We introduce the novel concept of graph alignment, a generalization of graph isomorphism that is motivated by the commonly used multiple sequence alignments. Graph alignments and graph isomorphisms are equivalent in the case of pairwise comparisons, but if many graphs should be analyzed simultaneously, graph alignments are more robust against noise and perturbations. Thus, graph alignments can ...

We present TranslatorX, a web server designed to align protein-coding nucleotide sequences based on their corresponding amino acid translations. Many comparisons between biological sequences (nucleic acids and proteins) involve the construction of multiple alignments. Alignments represent a statement regarding the homology between individual nucleotides or amino acids within homologous genes. A...

The multiple species de novo gene prediction problem can be stated as follows: given an alignment of genomic sequences from two or more organisms, predict the location and structure of all protein-coding genes in one or more of the sequences. Here, we present a new system, N-SCAN (a.k.a. TWINSCAN 3.0), for addressing this problem. N-SCAN can model the phylogenetic relationships between the alig...