Immunosuppressant peptide immunocortin for the first time was described in 1993. It corresponds to residues 11-20 of human Ig heavy chain (conserved motif of VH domain). There are no data about production of immunocortin by proteolysis of Ig in vivo. Synthetic immunocortin in concentration ~ 10-9 M suppresses phagocytosis in peritoneal macrophages, ConA-dependent blast transformation of rat lym...

Toll-like receptor (TLR) 4 is essential for the defense against infection with gram-negative pathogens, but reduced TLR4 expression has not been linked to altered disease susceptibility in humans. In mice, Tlr4 controls the mucosal response to Escherichia coli urinary tract infections. Inactivation of mouse Tlr4 causes an asymptomatic carrier state resembling asymptomatic bacteriuria (ABU). The...

8,117,523 132 * 2/2012 Divsalar et al . ............... 714/801 8,239,746 B2 * 8/2012 Divsalar et al . ............... 714/801 8,495,450 132 * 7/2013 Abu-Surra et al. ........... 714/752 8,560,911 132 * 10/2013 Abu-Surra et al. ........... 714/752 2006/0291571 Al 12/2006 Divsalar et al. 2006/0294445 Al 12/2006 Divsalar et al. 2007/0162815 Al* 7/2007 El-Khamy et al ............. 714/752 2007/028...

It has been recently pointed out by Arkani-Hamed and Dimopoulos that if the universe is a landscape of vacua, and if therefore fine-tuning is not a valid guidance principle for searching for physics beyond the standard model, supersymmetric unification only requires the fermionic superpartners. We argue that in that landscape scenario, the fermionic superpartners are not needed for unification,...

Petrological and geochemical examination of Upper Cretaceous chalks from the Abu Roash area and Bahariya Oasis (Egypt) provide insights into factors which control porosity development in fine-grained calcitic carbonates. Petrological studies indicate that primary skeletal fabrics of coccoliths and foraminifera in micrites of Abu Roash are well preserved. In contrast, primary skeletal fabrics of...

Gyrodactylus aff. mugili Zhukov, 1970 (Monogenoidea: gyrodactylidae) is recorded and described from the gill lamellae of 11 of 35 greenback mullet, Chelon subviridis (Valenciennes) (minimum prevalence 31%), from the brackish waters of the shatt Al-Arab Estuary in southern iraq. the gyrodactylid was also found on the gill lamellae of one of eight speigler’s mullet, Valamugil speigleri (Bleeker),...

Emergency Department and “Google Flu Trends” Data as Syndromic Surveillance Indicators for Seasonal Influenza L. H. Thompson, M. T. Malik, A. Gumel, T. Strome, and S. M. Mahmud 1. Department of Community Health Sciences, University of Manitoba, Winnipeg, MB 2. Department of Mathematics, University of Manitoba, Winnipeg, MB 3. Department of Applied Mathematics and Sciences, Khalifa University of...

Asymptomatic bacterial colonization of the urinary bladder (asymptomatic bacteriuria, ABU) can prevent bladder colonization by uropathogens and thus symptomatic urinary tract infection (UTI). Deliberate bladder colonization with Escherichia coli ABU isolate 83972 has been shown to outcompete uropathogens and prevent symptomatic UTI by bacterial interference. Many ABU isolates evolved from uropa...

The severity of urinary tract infection (UTI) reflects the quality and magnitude of the host response. While strong local and systemic innate immune activation occurs in patients with acute pyelonephritis, the response to asymptomatic bacteriuria (ABU) is low. The immune response repertoire in ABU has not been characterized, due to the inherent problem to distinguish bacterial differences from ...