Downloa 3. Andreou I, Tousoulis D, Miliou A, et al. Effects of rosuvastatin on myeloperoxidase levels in patients with chronic heart failure: a randomized placebo-controlled study. Atherosclerosis 2010;210:194–8. 4. Tousoulis D, Andreou I, Tsiatas M, et al. Effects of rosuvastatin and allopurinol on circulating endothelial progenitor cells in patients with congestive heart failure: the impact o...

BACKGROUND Despite numerous guidelines recommending prophylactic antibiotics prior to percutaneous endoscopic gastrostomy, their use remains controversial. AIM To conduct a systematic literature review and performed meta-analyses to determine the benefit of antibiotic prophylaxis for percutaneous endoscopic gastrostomy placement. METHODS We performed a systematic literature review by search...

BACKGROUND We analyzed the claim "mammography saves lives" by calculating the life-saving absolute benefit of screening mammography in reducing breast cancer mortality in women ages 40 to 65. METHODS To calculate the absolute benefit, we first estimated the screen-free absolute death risk from breast cancer by adjusting the Surveillance, Epidemiology and End Results Program 15-year cumulative...

Evidence-based practice (EBP) comprises a number of ‘‘tools’’ in its toolbox. These include (1) being able to phrase a question in such a way that you can carry out a useful literature search; (2) knowing how to do the search; and (3) having an understanding of the basic terminology, such as absolute risk reduction (ARR) and number needed to treat (NNT). This paper introduces the concepts of AR...

The medical research community is fairly unanimous in its agreement that Btranslating scientific discoveries^ and Btranslating research findings^ is important, but achieving translation remains a challenge [1]. There exists a research literature on strategies for knowledge dissemination or transfer [2]. In comparison, an equally important aspect of translation, the incorporation of research fin...

JNCI Vol. 103, Issue 13 | July 6, 2011 In this issue of the Journal, Petracci et al. (1) present a model to estimate the degree of benefit in terms of breast cancer risk reduction that may be achieved with risk factor modification. By how much would breast cancer risk change over a 10-year period for a 45-yearold Italian woman making changes in modifiable risk factors such as exercise, weight, ...