The thyroid is an endocrine gland in all vertebrates that develops from the ventral floor of the anterior pharyngeal endoderm. Unravelling the molecular mechanisms of thyroid development helps to understand congenital hypothyroidism caused by the absence or reduction of this gland in newborn humans. Severely reduced or absent thyroid-specific developmental genes concomitant with the complete lo...

Permanent primary congenital hypothyroidism (CH), the commonest cause of preventable intellectual disability, is due to defects in the embryonic development of the thyroid in the vast majority of cases. These defects are collectively called thyroid dysgenesis. The thyroid may be absent (athyreosis) but, more commonly, a sublingual thyroid ectopy without lateral lobes, is the only thyroid tissue...

OBJECTIVE Peptide receptor radionuclide therapy (PRRT) is dependent upon binding of radiolabelled peptides to their respective receptor expressing cells. The main objective of this study was to characterize the expression of somatostatin receptor (SSTR) subtypes in non-medullary thyroid cancers in order to be able to recommend the use of PRRT as a treatment option in patients with progressive l...

background: within the context of developing techniques to facilitate the diagnosis of the thyroid diseases, the elemental composition of pathological thyroid tissue (neoplastic and non-neoplastic) was investigated by proton induced x-ray emission. the pixe has been widely used as a sensitive technique for trace elemental analysis in both biological and medical fields. materials and methods: th...

Ectopic thyroid tissue is a rare entity resulting from developmental defects at early stages of thyroid gland embryogenesis, during its passage from the floor of the primitive foregut to its final pre-tracheal position. It is frequently found around the course of the thyroglossal duct or laterally in the neck, as well as in distant places such as the mediastinum and the subdiaphragmatic organs....

lingual thyroid (lt) is a rare developmental thyroid anomaly usually affecting. although the exact pathogenesis of this ectopic, accessory thyroid tissue is not known, it generally originates from epithelial tissue of non-obliterated thyroglossal ductus. in this report, a case of lingual thyroid in a 45- year old male patient with difficulty in breathing and swallowing complaints for five years...

NADPH oxidase 4 (NOX4) belongs to the NOX family that generates reactive oxygen species (ROS). Function and tissue distribution of NOX4 have not yet been entirely clarified. To date, in the thyroid gland, only DUOX1/2 NOX systems have been described. NOX4 mRNA expression, as shown by real-time PCR, was present in normal thyroid tissue, regulated by TSH and significantly increased in differentia...

Tumor models are needed to study cancer. Noninvasive imaging of tumors under native conditions in vivo is critical but challenging. Intravital microscopy (IVM) of subcutaneous tumors provides dynamic, continuous, long-term imaging at high resolution. Although popular, subcutaneous tumor models are often criticized for being ectopic and lacking orthotopic tissue microenvironments critical for pr...

A 22-year-old man presented with a 6-month history of dysphagia to solid food and intermittent spitting of blood for about 1 year. A lateral radiograph of the neck revealed a well-defined soft-tissue mass at the base of the tongue, compromising the oropharynx. After a series of tests, which included CT (Fig. 1) and radionuclide scintigraphy, the diagnosis of lingual thyroid was made. A thyroid ...

Lingual thyroid (LT) is a rare developmental thyroid anomaly usually affecting. Although the exact pathogenesis of this ectopic, accessory thyroid tissue is not known, it generally originates from epithelial tissue of non-obliterated thyroglossal ductus. In this report, a case of lingual thyroid in a 45- year old male patient with difficulty in breathing and swallowing complaints for five years...