Antibody-mediated rejection (AMR) is difficult to diagnose after ABO-compatible or ABO-identical (ABO-C) liver transplantation. To determine whether complement component 4d (C4d) immunostaining would be useful for diagnosing AMR, we compared the results of C4d immunohistochemistry for allograft biopsy samples with assays for anti-donor antibodies performed at the time of biopsy. One hundred fou...

BACKGROUND Loss of A, B and H antigens from the red blood cells of patients with myeloid malignancies is a frequent occurrence. Previously, we have reported alterations in ABH antigens on the red blood cells of 55% of patients with myeloid malignancies. METHODOLOGY/PRINCIPAL FINDINGS To determine the underlying molecular mechanisms of this loss, we assessed ABO allelic expression in 21 patien...

metabolic syndrome between native rural Abuja settlers and genetically related urban dwellers. Adediran O et al. observed that obesity, hypertriglycaeridemia, and hypertension are prevalent in urban than rural dweller, and metabolic syndrome was found to be significantly more frequent in females in age and gender-matched participants. These results suggest that metabolic syndrome is a major hea...

We investigated the ABO genotypes and heterogeneity of the O alleles in Plasmodium falciparum-infected and non-infected individuals from the Brazilian Amazon region. Sample collection took place from May 2003 to August 2005, from P. falciparum malaria patients from four endemic regions of the Brazilian Amazon. The control group consisted of donors from four blood banks in the same areas. DNA wa...

There is no scientific consensus that a relationship exists between the ABO blood group and personality traits. However, a recent study hypothesized that the dopamine beta-hydroxylase (DBH) gene is in linkage with the ABO gene. The sample population consisted of 1,427 healthy Japanese subjects who completed the Temperament and Character Inventory (TCI). Each subject's ABO blood type was determi...

Pancreatic cancer is among the most aggressive types of cancer. It has mortality rates as the seventh most frequent cause of cancer death worldwide. The association between ABO blood group and risk of pancreatic cancer has been known for more than 40 years.Various studies, in detail, although conflicting on many occasions, on large population groups, cohort studies, case-control studies, retros...

PURPOSE The number of patients waiting for kidney transplantation is incessantly increasing, but the number of cadaveric kidney transplantations or ABO-compatible donors is so insufficient that ABO-incompatible kidney transplantation is being performed as an alternative. There are overseas studies and research showing that the 5-year survival rate and 5-year graft survival rate of ABO-incompati...

We read with great interest the report entitled “ABO blood types: impact on development of prosthetic mechanical valve thrombosis” by Astarcıoğlu et al. (1) published in this current issue of The Anatolian Journal of Cardiology. ABO antigens are ubiquitously expressed on wide variety of eukaryotic cells, as well as erythroid/myeloid cell lineages of human bone marrow. Relevant to their involvem...

We examined the behavior of an autosomal recessive maternal-effect mutation, abnormal-oocyte (abo), that is located in the euchromatin of the left arm of chromosome 2. When homozygous in females, abo results in a marked reduction in the probability that an egg produced by a mutant mother will develop into an adult. However, this probability is increased if the fertilizing sperm delivers to the ...

Background—The purported advantage of ABO-incompatible (ABO-I) listing is to reduce wait times and wait-list mortality among infants awaiting heart transplantation. We sought to describe recent trends in ABO-I listing for US infants and to determine the impact of ABO-I listing on wait times and wait-list mortality. Methods and Results—In this multicenter retrospective cohort study using Organ P...