........................................................................................... 7 Populärvetenskaplig sammanfattning ............................................. 9 List of papers .................................................................................. 11 Abbrevations .................................................................................. 13 Introduction ..........

ACTA BIOLOGIAE EXPERIMENTALIS publish original papers on physiology and anatomy of the central nervous system with special reference to the physiology of the higher nervous activity, animal behaviour and related disciplines. The journal appears quarterly in issues of about 80 pages. Payments to the account of: Narodowy Bank Polski No. 1534-6-71. Orders for back volumes and sets should be adress...

Ferroptosis is a regulated cell death characterized by lethal accumulation of lipid peroxides due to an increase intracellular iron and decrease antioxidant capacity. The reduction activity obtained using chemical agents, such as erastin RSL3, the first one inhibiting transmembrane cystine-glutamate antiporter causing cysteine glutathione depletion second inactivating directly peroxidase 4 (GPX...

has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination. Citation for the published paper: Bengtsson, B and Heijl, A and Agardh, E "Visual fields correlate better than visual acuity to severity of diabetic retinopathy." Access to the published version may require journal subscription. Title: Visual fields correlate better than visual acuity to sev...

Background Around 25% to 50% of lupus patients may present with alterations in the liver enzymes variable severity including fulminant hepatic failure. 1 Objectives To study prevalence, aetiology and outcome hospitalized enzyme abnormalities. Methods We analysed all from June 2018–June 2021. Patients abnormal enzymes(>2 times Upper Limit Normal) 2 were identified categorized as per standard ...

Using serum-free conditions, human monocytederived dendritic cells (MoDCs) tend to mature insufficiently in a TH1-polarizing direction under approved and standardized clinical conditions. However, for the initiation of an efficient tumour antigen-specific cytotoxic T-cell response, the induction of a distinct TH1 response is favourable. Therefore, to improve TH1 polarisation, the influence of i...

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the industrialized countries and a growing concern for the developing world. The underlying cause of almost all CVD is atherosclerosis, a process that is characterized by a low-grade inflammation in the artery walls. This inflammation is believed to be initiated by components of low density lipoproteins which, upon ...

The rat glucocorticoid receptor confers hormone-dependent transcriptional enhancement when expressed in yeast, thereby enabling the genetic identification of nonreceptor proteins that function in the hormone signaltransduction pathway. We isolated a yeast mutant, leml, with increased sensitivity to dexamethasone and triamcinolone acetonide; responsiveness to a third agonist, deoxycorticosterone...

Induction of the neutral proteinase, collagenase, is a marker for a specific switch in gene expression observed in rabbit synovial fibroblasts . A variety of agents, including 120-tetradecanoylphorbol-13-acetate, cytochalasins B and D, trypsin, chymotrypsin, poly(2hydroxyethylmethacrylate), and trifluoperazine induced this change in gene expression . Induction of collagenase by these agents was...