PURPOSE Four members of the fibroblast growth factor receptor (FGFR) family transduce signals of a diverse group of FGF ligands. The FGFR2-IIIb isoform is abundantly present in the normal pituitary gland with contrasting down-regulation in neoplastic pituitary cells. cDNA profiling identified the cancer-testis antigen melanoma-associated antigen A3 (MAGE-A3) as a putative target negatively regu...

PURPOSE MAGE-A3 is a potential target for immunotherapy due to its tumor-specific nature and expression in several tumor types. Clinical data on MAGE-A3 immunotherapy have raised many questions that can only be addressed by using animal models. In the present study, different aspects of the murine anti-tumor immune responses induced by a recombinant MAGE-A3 protein (recMAGE-A3) in combination w...

We studied antegrade concealed conduction of atrial extrastimuli (A2) that blocked in the atrioventricular (AV) node in eight subjects, using a third extrastimulus (A3), coupled at decreasing coupling intervals to A2. Three A1-A2 intervals were tested in each subject: late (just shorter than AV nodal effective refractory period), intermediate, and early (just longer than atrial functional refra...

The UT-A1 and UT-A3 urea transporters are expressed in the terminal inner medullary collecting duct (IMCD) and play an important role in the production of concentrated urine. We showed that both hyperosmolarity and vasopressin increase urea permeability in perfused rat terminal IMCDs and that UT-A1 and UT-A3 accumulate in the plasma membrane in response to vasopressin. In this study, we investi...

We previously reported results of a phase II trial in which recombinant MAGE-A3 protein was administered with or without adjuvant AS02B to 18 non-small-cell lung cancer (NSCLC) patients after tumor resection. We found that the presence of adjuvant was essential for the development of humoral and cellular responses against selected MAGE-A3 epitopes. In our current study, 14 patients that still h...

Annexin A3 has been identified as a novel biomarker in different types of cancers. However, little is known about its clinical significances and and biological roles in gastric cancer. In this study, we assessed annexin A3 expression in 80 patients with gastric cancer and explore its correlation with prognosis Moreover, correlations with Ki-67, Bcl-2 and Bax were also investigated. Expression o...

Objective: To construct and identify recombinant expression of a therapeutic tumor vaccine with HBcAg as a vector. Methods: PCR primers were designed according to the gene sequences of restriction enzyme sites of recombinant pKK233.2-hepatitis B core antigen (HBcAg) and melanoma-associated antigen 3 (MAGE-A3: 112120aa). The target fragment of MAGE-A3 was synthesized and cloned to pKK233.2-HBcAg...

Let A3 be the set of all positive integers pqr, where p, q, r are primes and possibly two, but not all three of them are equal. For any n = pqr ∈ A3, define a function w by w(n) = P (p + q)P (p + r)P (q + r), where P (m) is the largest prime factor of m. It is clear that if n = pqr ∈ A3, then w(n) ∈ A3. For any n ∈ A3, define w0(n) = n, wi(n) = w(wi−1(n)) for i = 1, 2, . . . . An element n ∈ A3...

i=1 Ai \⋃ k 6=i Ak  , {∑10 j=1 1Aj = 1} . (b) Setting A1 := B, A2 = A \ B and A3 = A, we see that Aj, j = 1, 2, 3, form a partition of Ω. The σ-algebra generated by the partition consists of all possible unions of its elements: σ({A,B}) = σ({A1, A3, A3}) = {∅, A1, A2, A3, A1 ∪ A2, A1 ∪ A3, A2 ∪ A3,Ω}. (c) No, F is not a σ-algebra, as the second axiom (A.2) fails: (B1 ×B2) doesn’t have the sp...