نتایج جستجو برای: a crocin

تعداد نتایج: 13432037  

2012
Zahra Jahanbakhsh Bahram Rasoulian Mahvash Jafari Shahnaz Shekarforoush Mansour Esmailidehaj Mohammad taghi Mohammadi Hasan Aghai Maryam Salehi Ali Khoshbaten

The aim of the present study was to investigate the effects of crocin - a natural antioxidant derived from saffron - on cardiac reperfusion-induced arrhythmia and antioxidant systems such as catalase and superoxide dismutase (SOD) enzyme activities, glutathione (GSH) and malondialdehyde (MDA, as a marker of lipid peroxidation) levels. Rats in 4 experimental groups were administered crocin (20 m...

2014
Javad Raouf Sarshoori Mohammad Hossien Asadi Mohammad Taghi Mohammadi

OBJECTIVES Some histopathological alterations take place in the ischemic regions following brain ischemia. Recent studies have demonstrated some neuroprotective roles of crocin in different models of experimental cerebral ischemia. Here, we investigated the probable neuroprotective effects of crocin on the brain infarction and histopathological changes after transient model of focal cerebral is...

2015
Amir Abbas Farshid Esmaeal Tamaddonfard

OBJECTIVES Crocin and safranal, the major constituents of saffron, exert neuroprotective effects. In the present study, we investigated the effects of crocin and safranal (alone or in combination with insulin) on peripheral neuropathy in diabetic rats. MATERIALS AND METHODS Diabetes was induced by intraperitoneal (i.p.) injection of 60 mg/kg of streptozotocin (STZ) and confirmed by blood gluc...

2015
Faeze Vali Vahid Changizi Majid Safa

Background. Chemotherapy, radiotherapy, and surgery are routine treatments of breast cancer. However, these methods could only improve the living survival. Nowadays the combined therapy including herbals such as crocin is to study for improving breast cancer treatment. The purpose of this study was to evaluate the effects of crocin, paclitaxel, and radiation on MCF-7 cell. Methods. To evaluate ...

2017
Ali Javandoost Asma Afshari Irandokht Nikbakht-Jam Mohammad Khademi Saied Eslami Mina Nosrati Mojtaba Foroutan-Tanha Amirhossein Sahebkar Shima Tavalaie Majid Ghayour-Mobarhan Gordon Ferns Farzin Hadizadeh Abolghasem Tabassi Ahmad Mohajeri

BACKGROUND Metabolic syndrome is defined by insulin resistance and a clustering of other cardiovascular risk factors. Crocin is a carotenoid derived from the stigmas of the saffron flower and had previously been shown to affect lipid profile. However, the mechanism for this function is not well understood. The present trial aimed to investigate the possible effect of crocin on plasma levels of ...

2017
Aijia Ji Jing Jia Zhichao Xu Ying Li Wu Bi Fengming Ren Chunnian He Jie Liu Kaizhi Hu Jingyuan Song

Gardenia jasminoides is used in traditional Chinese medicine and has drawn attention as a rich source of crocin, a compound with reported activity against various cancers, depression and cardiovascular disease. However, genetic information on the crocin biosynthetic pathway of G. jasminoides is scarce. In this study, we performed a transcriptome analysis of the leaves, green fruits, and red fru...

2014
Peng-Chong Cao Wen-Xing Xiao Ya-Bo Yan Xiong Zhao Shuai Liu Jing Feng Wei Zhang Jun Wang Ya-Fei Feng Wei Lei

The purpose of this study was to investigate the therapeutic effects of crocin on ovariectomy-induced osteoporosis in rats. Female Sprague-Dawley rats were randomly assigned to a sham-operated group (sham) and five ovariectomy (OVX) subgroups, that is, OVX with vehicle (OVX), OVX with 17β-estradiol (E 2, 25 μg/kg/day), and OVX with graded crocin doses (5, 10, or 20 mg/kg/day). Daily oral admini...

2015
Soghra Mehri Khalil Abnous Alireza Khooei Seyed Hadi Mousavi Vahideh Motamed Shariaty Hossein Hosseinzadeh

OBJECTIVES Acrylamide (ACR) has many applications in different industries. ACR damages the central and the peripheral nervous system in human and animals. Importance of ACR-induced neurotoxicity encouraged researchers to find both different mechanisms involved in ACR neurotoxicity and potent neuroprotective agents. Therefore, this study was designed to investigate the protective effect of croci...

2016
Hossein Ali Safakhah Tahereh Taghavi Ali Rashidy-Pour Abbas Ali Vafaei Mina Sokhanvar Narges Mohebbi Mostafa Rezaei-Tavirani

This study was designed to investigate the therapeutic effects of saffron (Crocus sativus L.) and its main constituent crocin on neuropathic pain behavioral responses induced by chronic constriction injury (CCI) in rats. Adult male Wistar rats (200 to 250 g) were randomly assigned into 5 groups: Sham + saline, CCI + saline, CCI+ saffron (30 mg/kg), CCI + crocin (15 mg/kg) and CCI + crocin (30 m...

2017
Ghaidafeh Akbari Seyyed Ali Mard Mahin Dianat Esrafil Mansouri

Background. Liver ischemia-reperfusion (IR) injury is one of the chief etiologies of tissue damage during liver transplantation, hypovolemic shock, and so forth. This study aimed to evaluate hepatoprotective effect of crocin on IR injury and on microRNAs (miR-122 and miR-34a) expression. Materials and Methods. 32 rats were randomly divided into four groups: sham, IR, crocin pretreatment (Cr), a...

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