Background/Aim: The aim of this study was to evaluate the cytotoxic and apoptotic effects of chloroform extract (ASCH) from the seeds of Annona squamosa. Materials and Methods: MTT assay was employed to determine the cytotoxicity of the extract on A-549 and EAC cells and IC50 values were calculated. The apoptotic effects induced by the ASCH was evaluated by Acridine Orange Ethidium Bromide dual...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 207 No. 4 549–567 www.jcb.org/cgi/doi/10.1083/jcb.201404001 JCB 549 *Mohammed I. Ahmed and Majid Alam contributed equally to this paper. Correspondence to Natalia V. Botchkareva: [email protected] Abbreviations used in this paper: BIO, 6-bromoindirubin-3-oxime; Dox, doxycycline; DTG, double transgenic K14-rtTA/miR-214-TRE; E...

Treatment of Malignant Melanoma A. W. Levene, F.R.C.S ................... 545 Central-Core Disease and Malignant Hyperpyrexia D. G. F. Harriman, F.R.C.P., and F. R. Ellis, PH.D., F.F.A. R.C.S. ...................... 545 Cost of Drugs J. D. P. Graham, F.R.C.P.ED.; D. K. Bose, M.R.C.G.P ............................... 546 Sarcoid Heart Disease L. Rossi, M.D ........................... 546 Cutaneo...

Lung cancer, with high morbidity and mortality and poor prognosis, is a worldwide problem. Though rapid progress has been made in operation and other comprehensive treatment recently, the 5-year survival rate of lung cancer is not satisfactory. So doctors are aiming to find a new way of treatment, that is gene therapy (Tangney, 2010). VEGF-C is a specific lymphatic endothelial cell growth facto...

In flume and field experiments we demonstrate that interfacial water flows, generated when bottom currents interact with sea bed topography, provide a fast and efficient pathway for the transport of suspended phytoplankton into subsurface layers of permeable sandy sediments. The advective transport, associated with small mounds and ripples as commonly found on shelf sediments, increased penetra...

2S 0918–549 is a low-mass X-ray binary (LMXB) with a low optical to X-ray flux ratio. Probably it is an ultracompact binary with an orbital period shorter than 60 min. Such binaries cannot harbor hydrogen rich donor stars. As with other (sometimes confirmed) ultracompact LMXBs, 2S 0918–549 is observed to have a high neon-to-oxygen abundance ratio (Juett et al. 2001) which has been used to argue...

We have discovered three certain (SAXJ1324.5−6313, 2S 1711−339 and SAXJ1828.5−1037) and two likely (SAXJ1818.7+1424 and SAXJ2224.9+5421) new thermonuclear X-ray burst sources with the BeppoSAX Wide Field Cameras, and observed a second burst ever from a sixth one (2S 0918−549). Four of them (excluding 2S 1711−339 and 2S 0918−549) are newly detected X-ray sources from which we observed single bur...

Overexpression of neuropeptide Y (NPY) and its receptor system has been reported in various types of cancers. NPY Y5 receptor (Y5R) has been implicated in cell growth and angiogenesis. However, the role of Y5R in breast cancer is unknown. To identify the role of Y5R in breast cancer, we screened several breast cancer cell lines to examine the expression of Y5R and its function in breast cancer....