نتایج جستجو برای: 9 aryl 1
تعداد نتایج: 2997373 فیلتر نتایج به سال:
A ring-closing olefin metathesis reaction of tetra-kis-(all-yl-oxy)calix[4]arene gave the bis- calixarene, (15E,40E,60E)-65,74-bis-(prop-2-en-1-yl-oxy)-13,18,38,43,58,63-hexa-oxado-deca-cyclo-[28.26.8.7(20,36).1(11,45).1(51,55).0(5,57).0(7,12).0(19,24).0(26,64).0(32,37).0(44,49).1(68,72)]tetra-hepta-conta-1,3,5(57),7,9,11,15,19(24),20,22,26,28,30(64),32,34,36,40,44(49),45,47,51,53,55(65),60,68,...
the reaction of p-diketones 1 with phenyl hydrazine afforded 5-aryl-3-(1- methyl-5-nitro-2-imidazoly1)-1-phenylpyrazole (2) and 3-aryl-5-(1-methyl-5- nitro-2-imidazoly1) -1-phenylpyrazole (3). the reaction of diketones (1) with urea in the presence of p-toluenesulfonic acid gave 4-(or 6-)aryl-6-(or 4-)(1-methyl- 5-nitro-2-imidazolyl)-1-(lh)pyrimidones (4). the structures of all compounds were c...
Chart 1) were reported to inhibit colon and lung tumors in a patent literature. Subsequently, we found that 3-aryl b-carbolin-1-ones (2) inhibit the proliferation of HeLa cells with IC50 values in the low micromolar range and that the aromatic substitution on C3 in 2 proved to be essential for their biological activity. To broaden the scope of previous studies, aryl-substituted 2-pyridone-conta...
A series of Azetidinone; 3-chloro-1-{4-[8-(2hydroxy-4-methylphenyl)-6,10-dimethyl-4,12-diphenyl2,4,5,11,12-pentaazatricyclo[7.3.0.0 3,7 ]dodeca-1(9), 3(7), 5,10tetraen-2-yl]phenyl}-4-aryl azetidin-2-one (3a-e) and thiazolidinones; 3-{4-[8-(2-hydroxy-4-methylphenyl)-6,10dimethyl-4,12-diphenyl-2,4,5,11,12pentaazatricyclo[7.3.0.0 3,7 ]dodeca-1(9), 3(7), 5,10-tetraen-2yl]phenyl}-2-aryl-1,3-thiazoli...
A series of 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized as focal adhesion kinase (FAK) inhibitors using molecular modeling in conjunction with a co-crystal structure. Chemistry was developed to introduce functionality onto the 9-aryl ring, which resulted in the identification of potent FAK inhibitors. In particular, compound 32 possessed single-digit nanomolar IC(5...
In the title complex, [(C(4)H(9))(4)N](2)[Mo(6)O(18)(C(9)H(9)NO(2))]·0.5C(4)H(10)O, the aryl-imido ligand is linked to an Mo atom of the Lindqvist-type polyoxidometalate anion by an Mo N bond of 1.726 (4) Å. The Mo N-C angles are 160.7 (5) and 167.6(5)° because of disorder affecting the aryl group, and is typical for the imido monodentate behaviour described in analogous hybrids. Light componen...
Many directing group containing arenes can now be arylated or alkylated under palladium, rhodium, or ruthenium catalysis.1 Even arenes lacking traditional directing groups can be functionalized representing the most atom-efficient method for creation of arylaryl bonds.2 However, in this case, regioselectivity issues often are unsolved. An exception can be found in recent elegant work by Fagnou ...
The triplet aryl cation photochemically generated from fluoroquinolones bearing a fluoro atom at position 8 attacks guanosine monophosphate (k(r) > 10(9) M(-1)s(-1)) and forms covalent adducts. The reaction is a model for the implementation of oxygen-independent photochemotherapy.
The presence of substituents at designated sites about the chlorin macrocycle can alter the spectral properties, a phenomenon that can be probed through synthesis. Prior syntheses have provided access to chlorins bearing distinct aryl substituents (individually or collectively) at the 5, 10, and 15-positions, but not the 20-position. A new Western half (5-phenyl-2,3,4,5-tetrahydro-1,3,3-trimeth...
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