The aim of this paper is to describe innovations taking place in national nutrition surveys in the UK and the challenges of undertaking innovations in such settings. National nutrition surveys must be representative of the overall population in characteristics such as socio-economic circumstances, age, sex and region. High response rates are critical. Dietary assessment innovations must therefo...

Imperatorin (IMP) is the major active ingredient in many common medicinal herbs. We examined the irreversible inhibitory effect of IMP on CYP2B6. IMP produced a timeand concentrationdependent inactivation of CYP2B6. About 70% of activity of CYP2B6 was suppressed after its incubation with 1.5 mM IMP for 9 minutes. KI and kinact were found to be 0.498 mM and 0.079 min , respectively. The loss of ...

al monogamy4 and covert sex outside the main relationship. Delayed marriage and high divorce rates mean that growing numbers of individuals experience multiple sexual partners in a lifetime, and this greatly increases their exposure to infection. Furthermore, National Health and Social Life Survey data show that around 25% of men and 10% of women report extramarital or extracohabitational affai...

Rodent animal models have been widely used for studying neurologic and toxicological events associated with cocaine abuse. It is known that the mouse is more susceptible to cocaine-induced hepatotoxicity (CIH) than the rat. However, the causes behind this species-dependent sensitivity to cocaine have not been elucidated. In this study, cocaine metabolism in the mouse and rat was characterized t...

88 Infants and children are frequently brought to the emergency department in the setting of profound weakness. It is imperative to determine the etiology of this type of presentation to treat the child effectively. Neuromuscular disorders must be considered. This article explores 4 such diseases, including the Guillain-Barré syndrome, tick paralysis, botulism, and myasthenia gravis. Distinguis...

The chemical and mechanical properties of extracellular matrices (ECMs) modulate diverse aspects of cellular fates; however, how regional heterogeneity in ECM composition regulates developmental programs is not well understood. We discovered that fibronectin 1 (Fn1) is expressed in strikingly non-uniform patterns during mouse development, suggesting that regionalized synthesis of the ECM plays ...

ZnO nanoparticles (NPs) are engineered nanoparticles used in many commercial products inclusive of cosmetics, paints, textiles, and sanitary products. ZnO NPs are potent in protecting the skin against UV radiation so, they are used as ingredients in sunscreen and moisturizing creams/lotions and hence the study of their toxicity is essential. On the one hand, nanoparticles, due to their small si...