نتایج جستجو برای: 705 and 79
تعداد نتایج: 16836613 فیلتر نتایج به سال:
BACKGROUND Development of antiviral drugs that have broad-spectrum activity against a number of viral infections would be of significant benefit. Due to the evolution of resistance to currently licensed antiviral drugs, development of novel anti-influenza drugs is in progress, including Favipiravir (T-705), which is currently in human clinical trials. T-705 displays broad-spectrum in vitro acti...
Current anti-influenza therapy depends on administering drugs soon after infection, which is often impractical. We assessed whether combinations of oseltamivir (a neuraminidase inhibitor) and T-705 (a nonspecific inhibitor of viral polymerases) could extend the window for treating lethal infection with highly pathogenic A(H5N1) influenza virus in mice. Combination therapy protected 100% of mice...
It is worth keeping in mind the trade-off: Bayes estimators although easy to compute are somewhat subjective (in that they depend strongly on the prior π). Minimax estimators although more challenging to compute are not subjective, but do have the drawback that they are protecting against the worst-case which might lead to pessimistic conclusions, i.e. the minimax risk might be much higher than...
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