one of the mechanisms involved in the regulation of the immune system by steroid hormones could be the monocytic-macrophage system. in this study the effect of the male hormone 5a-dht on cytokine release by peritoneal macrophages (mφ) of male and female nzb/balbc mice was investigated. macrophages from male mice activated with lps produced a greater amount of il-1β (21.8%) (p<0.05) and il-6 (19...

BACKGROUND To determine: in vitro binding affinity of equol for 5alpha-dihydrotestosterone (5alpha-DHT), in vitro effects of equol treatment in human prostate cancer (LNCap) cells, and in vivo effects of equol on rat prostate weight and circulating levels of sex steroid hormones. METHODS First, in vitro equol binding affinity for 5alpha-DHT was determined using 14C5alpha-DHT combined with col...

To assess the possible modulatory effects of noradrenergic and serotoninergic neurons on dopaminergic neuronal activity, the noradrenergic and serotoninergic neurotoxins DSP-4 N-(2-chlorethyl)-N-ethyl-2-bromobenzylamine (50.0 mg/kg, sc) and 5,7-dihydroxytryptamine (5,7-DHT) (37.5 microg icv, half in each lateral ventricle), respectively, were administered toWistar rats on the first and third da...

Heat and drought stresses have negative impacts on wheat yield growth worldwide, causing up to 60% 40% losses, respectively, but their combined effect can cause severe losses. The present study aimed identify the high-yielding genetic resources tolerant and/or heat under climate change scenarios. field trials 42 genotypes were conducted at three locations in four environments (normal TSIR-NS, T...

Dexfenfluramine (dF) and dexnorfenfluramine (dNF), its metabolite, are anorectic agents that release serotonin (5-HT) and may have a direct postsynaptic action. The effects on the anorectic effects of dF and dNF of either acute (p-chlorophenylalanine, PCPA) or chronic (5,7-dihydroxytryptamine, 5,7-DHT) brain 5-HT depletions were studied in rats and compared with the actions of a 5-HT uptake inh...

The television show Mission Impossible began with Jim Phelps receiving instructions from a recording that subsequently self-destructs. This communication has strong privacy guarantees, but is not invulnerable to attack. The instructions can be overheard and even recorded. Instructions were often recieved in obscure locations, but it would be possible for someone other than Jim Phelps to listen ...

BACKGROUND The evaluation of prepubertal gonadal Leydig cells secretion requires gonadotropin stimulation. Urinary hCG (human chorionic gonadotropin) is currently unavailable in many countries, however, recombinant hCG (rhCG) can be used. Our aim was to evaluate rhCG-stimulated testicular hormones in a group of patients with cryptorchidism. METHODS We evaluated 31 prepubertal boys (age range,...

Granulosa cell mitogenesis is critical for the development of normal ovarian follicles. FSH and other mitogenic stimuli play a crucial role in this process. We have shown that exposing granulosa cells to 5alpha-dihydrotestosterone (DHT) reduces forskolin-stimulated cyclin D2 mRNA expression, which leads to cell cycle arrest resulting in reduced cell proliferation. The present study investigated...

Distributed Hash Table (DHT) plays an important role in distributed systems and applications, especially in large-scale distributed environments. In normal Client/Server model (C/S model) since most of the resources is centralized at server, it becomes the most important part as well as the bottleneck and weak point of the system. On the contrary, distributed model (a typical one is peer-to-pee...

The sex difference in the metabolism of certain mRNAs in the murine submaxillary gland (SMG) prompted us to determine whether androgens regulate the expression of any of the four isoforms of AUF1, proteins that bind differentially to AU-rich RNA. We found that cytosol from female SMGs contains two major isoforms (p45 and p40), whereas cytosol from male SMGs contains a prominent p37 and a weaker...