نتایج جستجو برای: 6r robot

تعداد نتایج: 108295  

2012
HEE YI HEE - JUNG CHO SOO - MIN CHO KYUL JO JIN - A PARK NA - HYUN KIM GORDON L. AMIDON JIN - SUK KIM

IL-6/6R signaling is closely associated with tumor growth and poor prognosis. Although there is evidence that interleukin-6 receptor (IL-6R)-mediated signaling promotes the growth and malignancy of cancer, the role of IL-6R in cancer stem cells (CSCs) is poorly defined. This study investigated the role of IL-6R in the proliferation of CSCs. Sphere-forming cells were isolated from the H460 non-s...

Journal: :The Journal of Experimental Medicine 1996
S Tajima K Tsuji Y Ebihara X Sui R Tanaka K Muraoka M Yoshida K Yamada K Yasukawa T Taga T Kishimoto T Nakahata

We recently demonstrated that stimulation of gp130 by a combination of soluble interleukin 6 receptor (sIL-6R) and IL-6 but not IL-6 alone significantly stimulates the ex vivo expansion of primitive hematopoietic progenitors and the generation of erythroid cells from human CD34+ cells in the presence of stem cell factor (SCF). Here, we show that gp130 is found low positively on most CD34+ cells...

1999
Xingwei Sui Kohichiro Tsuji Yasuhiro Ebihara Ryuhei Tanaka Kenji Muraoka Makoto Yoshida Kaoru Yamada Kiyoshi Yasukawa Tetsuya Taga Tadamitsu Kishimoto Tatsutoshi Nakahata

We have recently shown that stimulation of glycoprotein (gp) 130, the membrane-anchored signal transducing receptor component of IL-6, by a complex of human soluble interleukin-6 receptor (sIL-6R) and IL-6 (sIL-6R/IL-6), potently stimulates the ex vivo expansion as well as erythropoiesis of human stem/progenitor cells in the presence of stem cell factor (SCF). Here we show that sIL-6R dose-depe...

2014
Albert Nubiola Ilian A. Bonev

This paper presents a simple but efficient way to numerically calculate the inverse displacement problem of calibrated decoupled 6R serial robots. The method is iterative and works with any type of calibrated robot model, such as level-3 models, since it requires no algebraic computation and no resolution of high-order polynomials, only the computation of the forward displacement problem of the...

Journal: :The Journal of biological chemistry 2003
Vance Matthews Björn Schuster Stefan Schütze Ingo Bussmeyer Andreas Ludwig Christian Hundhausen Thorsten Sadowski Paul Saftig Dieter Hartmann Karl-Josef Kallen Stefan Rose-John

Interleukin-6 (IL-6) activates cells by binding to the membrane-bound IL-6 receptor (IL-6R) and subsequent formation of a glycoprotein 130 homodimer. Cells that express glycoprotein 130, but not the IL-6R, can be activated by IL-6 and the soluble IL-6R which is generated by shedding from the cell surface or by alternative splicing. Here we show that cholesterol depletion of cells with methyl-be...

2012
Stefan Rose-John

Interleukin-6 (IL-6) is a cytokine with many activities. It has functions in the regulation of the immune system and the nervous system. Furthermore, IL-6 is involved in liver regeneration and in the metabolic control of the body. On target cells, IL-6 binds to an 80 kDa IL-6 receptor (IL-6R). The complex of IL-6 and IL-6R associates with a second protein, gp130, which thereupon dimerizes and i...

Journal: :Exercise medicine (Online) 2021

Objectives: Genomic markers linked to exercise-associated health benefits and/or sporting performance are increasingly used guide decision-making in healthcare and sport/exercise science. This project investigated whether the IL-6R SNP “rs2228145” might be provisionally designated a novel physical activity/exercise marker. rs2228145 results an Aspartate358/Alanine358 change adjacent site where ...

2002
J. N. Varghese A. van Donkelaar H. Ji N. Ivancic K. M. Branson

Dysregulated production of IL-6 and its receptor (IL-6R) are implicated in the pathogenesis of multiple myeloma, autoimmune diseases and prostate cancer. The IL-6R complex comprises two molecules each of IL-6, IL-6R, and the signaling molecule, gp130. Here, we report the x-ray structure (2.4 Å) of the IL-6R ectodomains. The N-terminal strand of the Ig-like domain (D1) is disulfide-bonded to dom...

2017
Y. Chen S. Yang Y. Peng Z. Yang

This study investigated the expression and regulation of IL-6R in hepatitis B-associated moderate hepatic fibrosis and cirrhosis. Liver tissues, peripheral blood monocytes (PBMs) and serum were collected from 26 hepatitis B patients with liver fibrosis and 35 hepatitis B patients with liver cirrhosis. The levels of Il-6r mRNA expression in these samples were examined by quantitative real-time P...

Journal: :Human reproduction 2004
Souichi Yoshida Tasuku Harada Tomio Iwabe Fuminori Taniguchi Masahiro Mitsunari Nobuhiro Yamauchi Imari Deura Sayako Horie Naoki Terakawa

BACKGROUND We previously reported that the level of interleukin (IL)-6 is increased in the peritoneal fluid of women with endometriosis. This study was undertaken to assess the effects of IL-6 and soluble IL-6 receptor (sIL-6R) on in vitro sperm motility. METHODS Sperm (n = 20) were cultured with IL-6 or sIL-6R, or with a combination of both. After 24 h cultures, sperm motility was evaluated ...

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