Radiation therapy combined with adjuvant hyperthermia has the potential to provide outstanding local-regional control for refractory disease. However, achieving therapeutic thermal dose can be problematic. In the current investigation, we used a chemistry-driven approach with the goal of designing and synthesizing novel small molecules that could function as thermal radiosensitizers. (Z)-(+/-)-...

The aim of this study was to develop a novel multifunctional nanoparticle, which encapsulates SPION and Gemcitabine in PLGA ± PEG to form multifunctional drug delivery system. For this aim, super paramagnetic iron oxide nanoparticles (SPIONs) were simultaneously synthesized and encapsulated with Gemcitabine (Gem) in PLGA ± PEG copolymers via W/O/W double emulsification method. Optimum size and ...

Hyperthermia (HT) combined with irradiation is a well-known concept to improve the curative potential of radiotherapy. Technological progress has opened new avenues for thermoradiotherapy, even recurrent head and neck squamous cell carcinomas (HNSCC). Preclinical evaluation radiosensitizing various HT regimens remains ethically, economically, technically challenging. One key objective our study...

Hyperthermia (HT)--heating the tumor in the range of 40.0- 44.0 °C--combined with radiation (RT) and/or chemotherapy (CT) is a well proven treatment for malignant tumors. The improvement of the techniques for monitoring and adapting of the desired temperatures even in deep seated tumors has led to a renaissance of, now quality-controlled, HT in multimodal tumor therapy approaches. Randomized cl...

In using hyperthermia in the clinic, thermal dosimetry is essen tial and is discussed in terms of equating time-temperature relationships for an isoeffect to an equivalent time at a reference temperature, 43° for example. In applying time-temperatureequivalence, the sequence between heat and radiation and be tween two heat treatments, radiation dose rate, linear energy transfer, and physiologi...

Introduction: Hyperthermia (HT) in cancer management refers to the external application of heat raise intratumoural temperature between 39°C and 45°C. Locoregional hyperthermia (LRHT) is most used studied type HT care. A literature search was conducted produce a monograph help clinicians patients make informed choices considering this therapy.
 Methods: performed Medline Cochrane library f...

BACKGROUND AND OBJECTIVES Hyperthermia, either alone or in combination with anticancer drugs, is becoming more and more a clinical reality for the treatment of far advanced gastrointestinal cancers, acting as a cytotoxic agent at a temperature between 40-42.5 degrees C. Although hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) is demonstrated to have some benefit in selected pat...

Colony formation is the gold standard assay for determining reproductive cell death after radiation treatment, since effects on proliferation often do not reflect survival. We have developed a high-throughput radiosensitivity screening method based on clonogenicity and screened a siRNA library against kinases. Thiamine pyrophosphokinase-1 (TPK1), a key component of Vitamin B1/thiamine metabolis...