The purpose of this study was to characterize the hepatobiliary disposition of timosaponin B2 (TB-2), a natural saponin. Although TB-2 has multiple pharmacologic activities, the mechanism of its hepatobiliary disposition has not been explored. Because the metabolism of TB-2 is limited and the accumulation of TB-2 in primary hepatocytes is highly temperature dependent (93% of its accumulation is...

A no-till (NT) production system has potential to reduce soil erosion, fossil fuel consumption, and greenhouse gas emissions compared with a conventional till (CT) system. Nitrogen fertilization (four to six N rates) and tillage system (CT and NT) effects on irrigated, continuous corn (Zea mays L.) yields were evaluated for 5 yr on a clay loam soil to determine the viability of the NT system an...

This paper takes as its starting point the assumption that the «Epidemiological Imagination» has a central role to play in the future development of policies and practice to improve population health and reduce health inequalities within and between states but suggests that by neglecting the contribution that qualitative research can make epidemiology is failing to deliver this potential. The p...

Salmonella remains a threat to both animal and public health. Its economic significance remains high and changes in public perception mean that some measures for control may be necessary even in the absence of financial loss. Diagnosis is an important part of control. A great deal of new information has become available over the last few years as a result of research into various aspects of bot...

Mammalian mitochondrial DNA (mtDNA) is inherited principally down the maternal line, but the mechanisms involved are not fully understood. Females harboring a mixture of mutant and wild-type mtDNA (heteroplasmy) transmit a varying proportion of mutant mtDNA to their offspring. In humans with mtDNA disorders, the proportion of mutated mtDNA inherited from the mother correlates with disease sever...

t sounds like a paradox, but there is only one real trend evident in today's global market, and that is continuous – and rapid – change. The market environment is uncertain; competitors are changing; new, disruptive technologies are emerging; and topping all this, customers are becoming more demanding. To be successful in such a dynamic market, globally operating companies must be able to suppl...

0494 On 26 December 2004, Sri Lanka was affected, along with many other countries in the region, by deadly tsunami waves. The estimated death toll in Sri Lanka was more than 40,000; many more thousands of people were missing and displaced. Sri Lanka had not experienced a disaster of such magnitude in its 2,000 years of recorded history. The administrative, health, and judicial services were sim...