BACKGROUND AND PURPOSE The neutral results of the SAINT II trial have again highlighted difficulties translating neuroprotective efficacy from bench to bedside. Animal studies are susceptible to study quality biases, which may lead to overstatement of efficacy. We report the impact of study quality on published estimates of the efficacy of NXY-059 in animal models of stroke. METHODS We conduc...

The SAINT studies on NXY-0591,2 have reinvigorated debate over the momentous issues of neuroprotection and the development of novel stroke therapeutics. Some may argue there is little new ground that NXY-059 has unearthed and, in fact, the clinical trials merely confirm that as a strategy, neuroprotection has not been shown to be effective. Editorials in high-profile journals have sent out the ...

agers may organise the collection of resources and their transportation back to the nest. One way is to partition the task into a number of sequential stages in which material is passed from one worker to another in a relay fashion. This relatively new concept is known as task partitioning. In this study, we focus on a particular form of task partitioning, bucket brigades, which we define as a ...

The human liver cell line HepaRG has been recognized as a promising source for in vitro testing of metabolism and toxicity of compounds. However, currently the hepatic differentiation of these cells relies on exposure to dimethylsulfoxide (DMSO), which, as a side effect, has a cytotoxic effect and represses an all-round hepatic functionality. The AMC-bioartificial liver (AMC-BAL) is a three-dim...

Yoga in Modern Hinduism: Hariharananda Aranya and Samkhyayoga, by Knut A. Jacobsen. London: Routledge, 2018. 242 pp., £97.99 (hb). ISBN 978-1-13808-059-1.

The myalogenous leukemia call line K-562 with a Ph'+ chromosome, derived from a patient with chronic myalo ganous leukemia in terminal blashic crisis, is not a bone marrow-derived lymphoblastic call line, because the cells neither produce immunoglobulins nor possess complement receptors. Since it has been suspected that blasts found in some patients with chronic myelogenous leukemia in bIas tic...

The neutral results of the SAINT II study1 dashed the hopes for a second ischemic stroke drug in the near future. Although this is certainly disappointing for stroke neurologists, a careful analysis of the NXY-059 development program reveals several deficiencies, which if properly addressed, might revitalize and strengthen the field of neuroprotection for acute ischemic stroke. This critique po...

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Toxoplasmosis is caused by the intracellular protozoan Toxoplasma gondii. It is anopportunistic zoonosis in warm-blooded animals and humans, with a worldwide distribution. Toxoplasma gondii dense granule protein 16 (TgGRA16) can modulate some functions in host cells and is considered a significant virulent factor of the parasite. The present study reports sequence variation in TgGRA16 gene amon...

This project was designed to characterize olfactory tissue-specific proteins previously identified with a library of monoclonal antibodies raised against frog olfactory cilia. First, we showed that our olfactory tissue-specific monoclonal antibodies all recognize different molecular forms of the same protein. We named this protein "olfactomedin". We then proceeded to purify olfactomedin and cha...