We present a taxonomic revision of the crested newt Triturus karelinii sensu lato. Based on the presence of discrete nuclear DNA gene pools, deep genetic divergence of mitochondrial and nuclear DNA, and no indication of gene flow, we interpret this taxon as comprising two species: one covering the southern Caspian Sea shore, the Caucasus and the Crimea, i.e. the eastern part of the total range ...

Downlo PIM family of serine threonine protein kinases plays an important role in regulating both the growth and rmation of malignant cells. However, in a cell line–dependent manner, overexpression of PIM1 can t cell and tumor growth. In 22Rv1 human prostate cells, but not in Du145 or RWPE-2, PIM1 oversion was associated with marked increases in cellular senescence, as shown by changes in the le...

acrjourna h levels of the critical p53 inhibitor Mdm4 is common in tumors that retain a wild-type p53 allele, ting that Mdm4 overexpression is an important mechanism for p53 inactivation during tumorigenesis. t this hypothesis in vivo, we generated transgenic mice with widespread expression of Mdm4. Two ndent lines of transgenic mice, Mdm4 and Mdm4, developed spontaneous tumors, the most prevf ...

English teachers are frequently asked to help colleagues prepare presentations for internationalconferences. Sometimes this assistance takes the form of a language course or tutorials focusingon the spoken language. Contact time is short but the participants are highly motivated. Whattype of pronunciation work will provide the greatest payoff in terms of successfully beingunders...

This report summarizes the proceedings of the 6th and 7th workshops of the Genomic Standards Consortium (GSC), held back-to-back in 2008. GSC 6 focused on furthering the activities of GSC working groups, GSC 7 focused on outreach to the wider community. GSC 6 was held October 10-14, 2008 at the European Bioinformatics Institute, Cambridge, United Kingdom and included a two-day workshop focused ...