INTRODUCTION The incidence of actinic keratosis (AK) continues to increase worldwide. Currently available options for the treatment of AK include topical 5-fluorouracil (5-FU) and daylight-mediated photodynamic therapy (DL-PDT). This split-face pilot study compared DL-PDT using 16% methyl aminolevulinate (MAL) cream versus 5-FU cream in patients with AK on the face/scalp. METHODS Five male su...

OBJECTIVE To compare intravaginal 5-fluorouracil (5-FU) and placebo for the treatment of cervical and/or vaginal human papillomavirus (HPV). METHODS A randomized, placebo-controlled trial was performed. Women with HPV detected visually or by Papanicolaou (Pap) test and confirmed by colposcopic biopsy were randomized to receive either intravaginal 5-FU cream or an intravaginal placebo cream. W...

INTRODUCTION Patient treatment satisfaction and adherence may be affected by the initial understanding of outcomes in the treatment of actinic keratoses with 5-fluorouracil 5% cream (5-FU). Pre-treatment educational videos may optimize this understanding. The objective of this study was to determine whether prospective patient viewing of an educational video delineating treatment effects and ex...

Sir, Vulval intraepithelial neoplasia (VIN) is a form of squamous cell carcinoma (SCC) in situ. The condition presents as smooth or warty plaques on the vulva which are either erythematous or white in colour. The lesions can be asymptomatic or cause pruritus, vulval pain or sexual dysfunction. The disease is often multi-focal and almost always associated with human papilloma virus (HPV) type 16...