AIM We retrospectively investigated the relationship between IVS14+1 G > A genotype of the dihydropyrimidine dehydrogenase (DPD) gene with plasma concentration of 5-fluorouracil (5-FU) as well as adverse reactions in 80 patients with locally advanced or metastatic colorectal cancer. PATIENTS AND METHODS Eighty patients with un-resectable locally advanced or metastatic colorectal cancer were t...

Two common single nucleotide polymorphisms (SNPs) of the human TLR4 gene, namely Asp299Gly (D299G) and Thr399Ile (T399I), have been shown to impair the ability of certain individuals to respond properly to TLR4 ligands. 5-Fluorouracil (5-FU) is widely used for the treatment of patients with advanced colon cancers. The present study examined the impact of two common polymorphisms of the TLR4 gen...

We investigated the antitumor activities of 5-fluorouracil (5-FU), 5'-deoxy-5-fluorouridine (5'-DFUR), 1-hexylcarbamoyl-5-fluorouracil (HCFU) and 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT-207) in combination with hyperthermia in vitro. The antitumor effect of 5-FU (10(-4) M) was slightly enhanced by combination with hyperthermia (42 degrees C) for 2h, and the effect was determined to be addit...

This work aimed to overcome the main drawbacks of some essential anticancer drugs as 5-Fluorouracil (5-FU) by controlled loading with novel drug carriers. By a differential microemulsion technique, nanosized particles derived from copolymer poly(methyl methacrylate (MMA) and 2-hydroxyethyl (HEMA)) different monomer ratios have been synthesized used carrier. Poly(MMA-co-HEMA)/MWCNT nanocomposite...

KONISHI, Y., KANAMARU, R., IsHIoKA, C., ISHIKAWA, ., SHIBATA, H., WAKUI, A. and DEI, T. The Changes in the Levels of Dihydrofolate Reductase mRNA and Its Gene Dosage in 5-Fluorouracil-Resistant L1210 Cells. Tohoku J. Exp. Med., 1990, 161(1), 33-42 5-Fluorouracil (5-FU)-resistant L1210 cell line (L1210/ 5-FU-1) was established in this laboratory, and maintained by serial passage in the peritonea...

5-fluorouracil (5-FU) is a potent antineoplastic agent used for the treatment of various malignancies. The L-argininenitric oxide (NO) pathway involved in the pathogenesis of chemotherapy induced kidney damage. This work investigated the beneficial mechanism of L-arginine supplementation in 5 FU induced nephropathy. Eighty male Wistar rats were divided into four equal groups: Control group; L-a...