نتایج جستجو برای: 5 شلایرماخر2

تعداد نتایج: 1215766  

2017
Ashley H. Ramsawhook Lara C. Lewis Maria Eleftheriou Abdulkadir Abakir Paulina Durczak Robert Markus Seema Rajani Nicholas R.F. Hannan Beth Coyle Alexey Ruzov

For several decades, 5-methylcytosine (5mC) has been thought to be the only DNA modification with a functional significance in metazoans. The discovery of enzymatic oxidation of 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) as well as detection of N6-methyladenine (6mA) in the DNA of multicellular organisms provided additional degrees of complexity ...

2015
Daniel Gackowski Ewelina Zarakowska Marta Starczak Martyna Modrzejewska Ryszard Olinski Wendy Dean

BACKGROUND Replication-independent active/enzymatic demethylation may be an important process in the functioning of somatic cells. The most plausible mechanisms of active 5-methylcytosine demethylation, leading to activation of previously silenced genes, involve ten-eleven translocation (TET) proteins that participate in oxidation of 5-methylcytosine to 5-hydroxymethylcytosine which can be furt...

Journal: :Nucleic acids research 2004
Mayumi Matsubara Tamon Tanaka Hiroaki Terato Eiji Ohmae Shunsuke Izumi Katsuo Katayanagi Hiroshi Ide

Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1), previously thought to be a backup enzyme for uracil-DNA glycosylase, has recently been shown to excise 5-hydroxyuracil (hoU), 5-hydroxymethyluracil (hmU) and 5-formyluracil (fU) bearing an oxidized group at ring C5 as well as an uracil. In the present study, we used site-directed mutagenesis to construct a series of mutants ...

Journal: :The Journal of the Institute of Television Engineers of Japan 1976

Journal: :Emerging Infectious Diseases 2000

Journal: :Healthcare Quarterly 2013

Journal: :Revista de Medicina y Cine / Journal of Medicine and Movies 2021

A lo largo de la historia diferentes pandemias han asolado a humanidad. De todas ellas, salvo Covid-19, pues aún no ha habido tiempo llevarla gran pantalla, numerosas representaciones en el cine comercial, algunas muy relevantes desde punto vista calidad cinematográfica y científica con que están documentados los guiones. Sería inalcanzable enumerar cada una ellas. Por tanto, este artículo se p...

Journal: :Chemical communications 2017
W L Yeo X Chew D J Smith K P Chan H Sun H Zhao Y H Lim E L Ang

Molecular determinants of FlA1 fluorinase specificity were probed using 5'-chloro-5'-deoxyadenosine (5'-ClDA) analogs as substrates and FlA1 active site mutants. Modifications at F213 or A279 residues are beneficial towards these modified substrates, including 5'-chloro-5'-deoxy-2-ethynyladenosine, ClDEA (>10-fold activity improvement), and conferred novel activity towards substrates not readil...

2016
Osama K. Zahid Boxuan Simen Zhao Chuan He Adam R. Hall

5-hydroxymethylcytosine (5 hmC), the oxidized form of 5-methylcytosine (5 mC), is a base modification with emerging importance in biology and disease. However, like most epigenetic elements, it is transparent to many conventional genetic techniques and is thus challenging to probe. Here, we report a rapid solid-state nanopore assay that is capable of resolving 5 hmC with high specificity and se...

Journal: :The Journal of the Institute of Television Engineers of Japan 1977

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