Hematopoietic cells present in the liver in early human fetal life were characterized by phenotypic analysis using a broad panel of monoclonal antibodies. Expression of very late antigen 4 and leukocyte function-associated antigen 3 cell adhesion receptors and 4F2 cell activation molecules was found in all fetal liver hematopoietic cells before acquisition of T cell-, B cell-, or myeloid-specif...

Following immunization with PPS, there is a transient but considerable enrichment in the peripheral blood of activated PPS-specific B cells. The activated cells are large, 4F2 positive, surface IgG positive and IgD negative, responsive to BCGF but refractory to anti-mu or SAC. The analysis of B lymphocyte physiology in terms of activation states which have precise signal requirements for the tr...

Samples of BaFe12O19 M-type barium hexaferrite with partial iron substitution by zirconium ions (concentration up to 10 at.%) have been synthesized and investigated. Studies crystal features, phase composition, magnetic properties were carried out using X-ray diffraction, Mössbauer spectroscopy, VSM respectively. The presence limited heterovalent isomorphism the 2Fe3+ → Zr4+ + Fe2+ mechanism wa...

Human T cells stimulated in secondary allogeneic mixed lymphocyte culture (MLC) were cloned under limiting conditions in microculture systems using T cell growth factor and irradiated allogeneic cells. Clones with lytic activity against either phytohemagglutinin-induced blast cells bearing the stimulating alloantigen(s) (cytotoxic T lymphocyte [CTL] activity), L1210 mouse lymphoma cells coated ...

The organic mercury compound methylmercury (MeHg) is able to target the fetal brain. However, the uptake of the toxicant into placental cells is incompletely understood. MeHg strongly binds to thiol-S containing molecules such as cysteine. This MeHg-l-cysteine exhibits some structural similarity to methionine. System L plays a crucial role in placental transport of essential amino acids such as...