نتایج جستجو برای: 429
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Epithelial-mesenchymal transition (EMT) accompanying loss of E-cadherin is important for invasiveness and metastasis of bladder cancer. MicroRNAs (miRs) had been associated with cancer progression and differentiation in several cancers. Our goal is to find out the specific miR which modulates EMT in bladder cancer. Real-time quantitative polymerase chain reaction was used to measure the miRs ex...
Prevalence of Eimeria species parasitizing rabbits (Oryctolagus cuniculus) in Taiwan were investigated. Six Eimeria species, namely: Eimeria media (prevalence, 158/642; 24.6%), Eimeria magna (101/642; 15.7%), Eimeria perforans (58/642; 9.0%), Eimeria coecicola (46/642; 7.2%), Eimeria piriformis (16/642; 2.5%), and Eimeria exigua (9/642; 1.4%) were observed. The overall prevalence of these cocci...
BACKGROUND 5-Fluorouracil (5-FU) based treatment is the standard therapy for metastatic colorectal cancer (CRC), but the development of chemoresistance is inevitable. Increasing evidence shows that dysregulation of microRNAs (miRNAs) is involved in malignant transformation. Thus, it is imperative that we find new diagnostic and prognostic marker for chemotherapy in CRC. MATERIAL AND METHODS For...
The transcription factor AP-2α functions as a tumor suppressor by regulating various genes that are involved in cell proliferation and apoptosis. Chemotherapeutic drugs including cisplatin induce post-transcriptionally endogenous AP-2α, which contributes to chemosensitivity by enhancing therapy-induced apoptosis. microRNAs (miRNAs) miR-200b, miR-200c and miR-429 (miR-200b/200c/429) are up-regul...
OBJECTIVE Liver tumour-initiating cells (T-ICs) are critical for hepatocarcinogenesis. However, the underlying mechanism regulating the function of liver T-ICs remains unclear. METHODS Tissue microarrays containing 242 hepatocellular carcinoma (HCC) samples were used for prognostic analysis. Magnetically activated cell sorting was used to isolate epithelial cell adhesion molecule (EPCAM)-posi...
H(2)S functions as a neuromodulator and exerts anti-inflammatory activities. Recent data indicate that irritable bowel syndrome (IBS) is linked to inflammation of the gastrointestinal tract. In this study, we have investigated the role of a novel H(2)S-releasing derivative of mesalamine (5-amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3yl)-phenyl ester, ATB-429) in modulating nocicept...
Human placental and germ cell alkaline phosphatases (PLAP and GCAP, respectively), are characterized by their differential sensitivities to inhibition by L-leucine, EDTA, and heat. Yet, they differ by only 7 amino acids at positions 15, 67, 68, 84, 241, 254, and 429 within their respective 484 residues. To determine the structural basis and the amino acid(s) involved in these physicochemical di...
WHERE HAS THE FIELD OF OB BEEN? .... . . . . . . .. . . . . ... . .. ........ . . . . . . . ..... . ......... 429 What Is OB?...................... ................. . ................... . . ... . .. ............ . . ..... 429 Themes in OB.Research............................. ............. ...... .......... . .............. 429 WHERE IS THE FIELD OF MICRO-OB TODAY? ..............................
Loss of epithelial organization and deregulated microRNAs are hallmarks of malignant carcinomas, but the relationship between them has been poorly understood. This study was designed to investigate the changes in the expression of E-cadherin, Par3, and miR-429 during the development of human colorectal cancer (CRC). E-cadherin and Par3 levels were quantitatively detected by immunohistochemistry...
the purpose of this research was to investigate the effect of mir-429 ectopic over-expression on u251 glioblastoma cell line. it has been shown that mir-429 could target bmk1 and reduce glioma cells invasion. we cultured u251-mir-429 cells and observed changes in their morphology for 14 days. they seemed to become wider with expanded cytoplasm and go on differentiation. neuronal (nefm, nse and ...
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