celecoxib is a non-steroidal anti-inflammatory drug (nsaid) developed as a selective inhibitor of cyclooxygenase-2 (cox-2) for the treatment of rheumatoid arthritis disease. recently some other mechanisms have been identified for anti cancer activity of these agents including induction of apoptosis, inhibition of tumor vascularization, stimulation of antitumor immune responses and inhibition of...

Background: A growing body of literature has revealed the effective role of miR-34a, as a tumor suppressor and regulator of expression of multiple targets in tumorigenesis and cancer progression. This study aimed at evaluating the potential effects of miR-34a alone or in combination with paclitaxel on breast cancer cells. Methods: After miR-34a transduction by lentiviral vectors in two MCF-7 an...

Bone metastasis is one of the most severe cancer complications. To analyze the mechanism of bone metastasis, we established highly invasive cell lines from the human breast cancer cell line MDA-MB-231 using an in vitro sequential selection system. The cell lines, MDA-231-S10 and MDA-231-S5, were more invasive and more motile than the parental cell line. Moreover, MDA-231-S10 metastasized to bon...

ing UML Behavior Diagrams for Verification María del Mar Gallardo, Jesús Martinez, Pedro Merino and Ernesto Pimentel (2005). Software Evolution with UML and XML (pp. 296-320). www.irma-international.org/chapter/abstracting-uml-behavior-diagramsverification/29617/ Security Issues in Outsourced XML Databases Tran Khanh Dang (2009). Open and Novel Issues in XML Database Applications: Future Direct...

tensin, vasopressin and methoxamine on cardiac function and blood flow distribution in conscious dogs. Am J Physiol 231: 1979, 1976 24. Landymore RW, Murphy DA, Kinley CE, Parrott JC, Moffit EA, Longley WJ, Qirbi AA: Does pulsatile flow influence the incidence of postoperative hypertension? Ann Thorac Surg 28: 261, 1979 25. Watkins WD, Moss J, Lappas DG, Levine L, Peterson MB: Vasoactive mediat...

Background: Despite modern developments in its management, still major concerns remain about drug resistance in chemotherapy. Natural adjuvants combined with chemotherapy might be the answer. We examined the anti-cancer, anti-proliferative and synergistic effects of Sambucus nigra extract with cisplatin chemotherapy (CDDP) on MCF-7 and MDA-MB-231 human cancer cell lines. Methods: MCF-7 and MDA...

Under 5 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 194 6.5 5 to 9 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 183 6.1 10 to 14 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 197 6.6 15 to 19 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 197 6.6 20 to 24 years . . . . . . . . . . . . . . . . . . . . ....

Volume 61, no. 2, p. 419, column 1, lines 15-19: this sentence should read as follows. "The alcohol dehydrogenase and glucose dehydrogenase have a common region reported to be related to pyrroloquinoline quinone binding (2, 10), but SNDH does not contain such a region, indicating that SNDH is not a quinoprotein." Page 419, column 2, line 12: "(Table 4)" should read "(Table 3)." [This corrects t...

Radiotherapy is one of the main options to cure and control breast cancer. The aim this study was investigate sensitivity two human cancer cell lines, MCF7 MDA-MD-231, radiation exposure at timepoints 4 h 24 after radiation. MDA-MD-231 were irradiated with different doses using a Gilardoni CHF 320 G X-ray generator (Mandello del Lario, Italy) 250 kVp, 15 mA [with half-value layer (HVL) = 1.6 mm...